Publications – Bioassay lab:
  1. Shaban Ahmad, Akash Pratap Singh, Nagmi Bano, Khalid Raza, Janmejay Singh, Guruprasad R. Medigeshi, Rajesh Pandey, Hemant K. Gautam. Integrative analysis discovers Imidurea as dual multitargeted inhibitor of CD69, CD40, SHP2, lysozyme, GATA3, cCBL, and S-cysteinase from SARS-CoV-2 and M. tuberculosis. International Journal of Biological Macromolecules, Int J Biol Macromol . 2024 May 18;270(Pt 2):132332. doi: 10.1016/j.ijbiomac.2024.132332.
  2. Janmejay Singh, Anbalagan Anantharaj , Parveen Kumar, Rajesh Pandey, Anil Kumar Pandey, Guruprasad R Medigeshi. The Effective Inhibitory Concentration of Interferon-β Correlates with Infectivity and Replication Fitness of SARS-CoV-2 Variants. J Interferon Cytokine Res 2024 Apr 1. doi: 10.1089/jir.2024.0016.
  3. Mark Manak, Luc Gagnon, Steven Phay-Tran,Philipa Levesque-Damphousse, Aymeric Fabie,Matthieu Daugan, Sarwat Tahsin Khan, Pamela Proud, Bethan Hussey, Daniel Knott, Sue Charlton, Bassam Hallis, Prof Guruprasad R Medigeshi, Neha Garg, Anbalagan Anantharaj, Rubhana Raqib, Protim Sarker, Mohammad Mamun Alam, Mustafizur Rahman, Marta Murreddu, Angela Balgobind Rick Hofman, Silvia Grappi, Rosa Coluccio, Pierpaolo Calandro, Emanuele Montomoli, Giada Mattiuzzo, Sandra Prior, Yann Le Duff, Mark Page, Jane Mitchell, Lauren M Schwartz, Yannic C Bartsch, Ali Azizi, Valentina Bernasconi, on behalf of theCEPI CLN Study Group.Standardised quantitative assays for anti-SARS-CoV-2 immune response used in vaccine clinical trials by the CEPI Centralized Laboratory Network: a qualification analysis. Lancet Microbe, March 2024, 5 (3), E216-E225.
  4. Janmejay Singh, Anbalagan Anantharaj, Aleksha Panwar, Chitra Rani,Monika Bhardwaj,Parveen Kumar,Partha Chattopadhyay,Priti Devi,Ranjeet Maurya,Pallavi Mishra,Anil Kumar Pandey,Rajesh Pandey,Guruprasad R. Medigeshi. BA.1, BA.2 and BA.2.75 variants show comparable replication kinetics, reduced impact on epithelial barrier and elicit cross-neutralizing antibodies. PLoS Pathog, 2023, 19(2): e1011196. https://doi.org/10.1371/journal.ppat.1011196.
  5. Suprit Deshpande, Mohammed Yousuf Ansari, Jyoti Sutar,, Payel Das, Nitin Hingankar, Sohini Mukherjee,, Priyanka Jayal, Savita Singh, Anbalagan Anantharaj,, Janmejay Singh, Souvick Chattopadhyay, Sreevatsan Raghavan, Mudita Gosain, Supriya Chauhan, Shweta Shrivas, Chaman Prasad, Sangeeta Chauhan, Neha Sharma, Pradipta Jana, Ramachandran Thiruvengadam, Pallavi Kshetrapal, Nitya Wadhwa, Bhabatosh Das, Gaurav Batra, Guruprasad Medigeshi, Devin Sok, Shinjini Bhatnagar, Pramod Kuma, Jayanta Bhattacharya. Ancestral SARS-CoV-2-Driven Antibody Repertoire Diversity in an Unvaccinated Individual Correlates with Expanded Neutralization Breadth. Microbiology Spectrum. March/April 2023 Volume 11 Issue 2 e04332-22.
  6. Subhash Thuluva, Vikram Paradkar, SubbaReddy Gunneri, Vijay Yerroju, Rammohan Mogulla, Pothakamuri Venkata Suneetha, Kishore Turaga, Mahesh Kyasani, Senthil Kumar Manoharan, Srikanth Adabala, Aditya Sri Javvadi, Guruprasad Medigeshi, Janmejay Singh, Heena Shaman, Akshay Binayke, Aymaan Zaheer, Amit Awasthi, Chandramani Singh, Venkateshwar Rao A, Indranil Basu, Khobragade Akash Ashok Kumar & Anil Kumar Pandey. Immunogenicity and safety of Biological E’s CORBEVAX™ vaccine compared to COVISHIELD™ (ChAdOx1 nCoV-19) vaccine studied in a phase-3, single blind, multicentre, randomized clinical trial, Human Vaccines & Immunotherapeutics, 2023, Volume 19 Issue 1, DOI: 10.1080/21645515.2023.2203632.
  7. Anbalagan Anantharaj, Tanvi Agrawal, Pooja Kumari Shashi, Alok Tripathi, Parveen Kumar, Imran Khan, Madhu Pareek, Balwant Singh, Chitra Pattabiraman, Saurabh Kumar, Rajesh Pandey, Anmol Chandele, Rakesh Lodha, Stephen S Whitehead, Guruprasad R Medigeshi. Neutralizing antibodies from prior exposure to dengue virus negatively correlate with viremia on re-infection. Commun Med, 2023, 3, 148.
  8. Zaigham Abbas Rizvi, Jyotsna Dandotiya, Srikanth Sadhu, Ritika Khatri, Janmejay Singh, Virendra Singh, Neeta Adhikari, Kritika Sharma, Vinayake Das, Amit Kumar Pandey, Bhabatosh Das, Guruprasad Medigeshi, Shalendra Mani, Shinjini Bhatnagar, Sweety Samal, Anil Kumar Pandey, Pramod Kumar Garg & Amit Awasthi. Omicron sub-lineage BA.5 infection results in attenuated pathology in hACE2 transgenic mice. Commun Biol, 2023,6, 935 (2023).
  9. Das S, Singh J, Shaman H, Singh B, Anantharaj A, Sharanabasava P, Pandey R, Lodha R, Pandey AK, Medigeshi GR. Pre-existing antibody levels negatively correlate with antibody titers after a single dose of BBV152 vaccination. Nat Commun. 2022;13(1):3451. Epub 20220615. doi: 10.1038/s41467-022-31170-1. PubMed PMID: 35705548.
  10. Medigeshi GR, Batra G, Murugesan DR, Thiruvengadam R, Chattopadhyay S, Das B, Gosain M, Ayushi, Singh J, Anbalagan A, Shaman H, Pargai K, Mehdi F, Das SJ, Kahlon N, Singh S, Kshetrapal P, Wadhwa N, Pandey AK, Bhatnagar S, Garg PK. Sub-optimal neutralisation of omicron (B.1.1.529) variant by antibodies induced by vaccine alone or SARS-CoV-2 Infection plus vaccine (hybrid immunity) post 6-months. EBioMedicine. 2022; 78:103938. Epub 20220316. doi: 10.1016/j.ebiom.2022.103938. PubMed PMID: 35305396; PMCID: PMC8923830.
  11. Parray HA, Narayanan N, Garg S, Rizvi ZA, Shrivastava T, Kushwaha S, Singh J, Murugavelu P, Anantharaj A, Mehdi F, Raj N, Singh S, Dandotiya J, Lukose A, Jamwal D, Kumar S, Chiranjivi AK, Dhyani S, Mishra N, Kumar S, Jakhar K, Sonar S, Panchal AK, Tripathy MR, Chowdhury SR, Ahmed S, Samal S, Mani S, Bhattacharyya S, Das S, Sinha S, Luthra K, Batra G, Sehgal D, Medigeshi GR, Sharma C, Awasthi A, Garg PK, Nair DT, Kumar R. A broadly neutralizing monoclonal antibody overcomes the mutational landscape of emerging SARS-CoV-2 variants of concern. PLoS Pathog. 2022 Dec 12;18(12):e1010994. doi: 10.1371/journal.ppat.1010994
  12. Subhash Thuluva, Vikram Paradkar, SubbaReddy Gunneri, Vijay Yerroju, Rammohan Reddy Mogulla, Pothakamuri Venkata Suneetha, Kishore Turaga, Mahesh Kyasani, Senthil Kumar Manoharan, Srikanth Adabala, Aditya Sri Javvadi, Guruprasad Medigeshi, Janmejay Singh, Heena Shaman, Akshay Binayke, Aymaan Zaheer, Amit Awasthi, Manish Narang, Pradeep Nanjappa, Niranjana Mahantshetti, Bishan Swarup Garg, Anil Kumar Pandey. Safety, tolerability and immunogenicity of Biological E’s CORBEVAX™ vaccine in children and adolescents: A prospective, randomised, double-blind, placebo controlled, phase-2/3 study. Vaccine, 2022, Volume 40, Issue 49, , Pages 7130-7140,ISSN 0264-410X,https://doi.org/10.1016/j.vaccine.2022.10.045.
  13. Thuluva S, Paradkar V, Gunneri SR, Yerroju V, Mogulla R, Turaga K, Kyasani M, Manoharan SK, Medigeshi G, Singh J, Shaman H, Singh C, Rao A V. Evaluation of safety and immunogenicity of receptor-binding domain-based COVID-19 vaccine (Corbevax) to select the optimum formulation in open-label, multicentre, and randomised phase-1/2 and phase-2 clinical trials. EBioMedicine.2022Sep:83:104217.doi: 10.1016/j.ebiom.2022.104217 Epub 2022 Aug 12. PMID: 35970020; PMCID: PMC9372721.
  14. Puneet Misra , Shashi Kant , Randeep Guleria , Sanjay K Rai , Abhishek Jaiswal , Suprakash Mandal , Guruprasad R Medigeshi , Mohammad Ahmad , Anisur Rahman , Meenu Sangral , Kapil Yadav , Mohan Bairwa , Partha Haldar , Parveen Kumar . Antibody Response to SARS-CoV-2 among COVID-19 Confirmed Cases and Correlates with Neutralizing Assay in a Subgroup of Patients in Delhi National Capital Region, India. Vaccines 2022, 10, 1312. https://doi.org/10.3390/vaccines10081312.
  15. Puneet Misra,Shashi Kant,Randeep Guleria,Mohammad Ahmad, Suprakash Mandal, P. K. Chaturvedi,Guruprasad R. Medigeshi, Suneeta Meena, Sanjay Kumar Rai,Anisur Rahman, Meenu Sangral, Kapil Yadav, Mohan Bairwa, and Partha Haldar. Test concordance and diagnostic accuracy of three serological assays for detection of anti-SARS-CoV-2 antibody: result from a population-based sero-epidemiological study in Delhi. BMC Infect Dis. 2022 Dec 7;22(1):915. doi: 10.1186/s12879-022-07805-5. PMID: 36476336; PMCID: PMC9730.
  16. Anantharaj A, Gujjar S, Verma N, Khan NA, Shaman H, Sharanabasava P, Das A, Pandey R, Pandey AK, Medigeshi GR. Resolution of viral load in mild COVID-19 patients is associated with both innate and adaptive immune responses. J Clin Virol. 2022; 146:105060. Epub 20211221. doi: 10.1016/j.jcv.2021.105060. PubMed PMID: 34971849; PMCID: PMC8687718.
  17. Dhochak N, Agrawal T, Shaman H, Khan NA, Kumar P, Kabra SK, Medigeshi GR, Lodha R. Humoral cross-reactivity towards SARS-CoV-2 in young children with acute respiratory infection with low-pathogenicity coronaviruses. J Clin Virol Plus. 2022;2(1):100061. Epub 20220111. doi: 10.1016/j.jcvp.2022.100061. PubMed PMID: 35262034; PMCID: PMC8747779.
  18. Thiruvengadam R, Awasthi A, Medigeshi G, Bhattacharya S, Mani S, Sivasubbu S, Shrivastava T, Samal S, Rathna Murugesan D, Koundinya Desiraju B, Kshetrapal P, Pandey R, Scaria V, Kumar Malik P, Taneja J, Binayke A, Vohra T, Zaheer A, Rathore D, Ahmad Khan N, Shaman H, Ahmed S, Kumar R, Deshpande S, Subramani C, Wadhwa N, Gupta N, Pandey AK, Bhattacharya J, Agrawal A, Vrati S, Bhatnagar S, Garg PK, Department of Biotechnology India Consortium for C-r. Effectiveness of ChAdOx1 nCoV-19 vaccine against SARS-CoV-2 infection during the delta (B.1.617.2) variant surge in India: a test-negative, case-control study and a mechanistic study of post-vaccination immune responses. Lancet Infect Dis. 2022;22(4):473-82. Epub 20211125. doi: 10.1016/S1473-3099(21)00680-0. PubMed PMID: 34838183; PMCID: PMC8616567.
  19. Sankaradoss A, Jagtap S, Nazir J, Moula SE, Modak A, Fialho J, Iyer M, Shastri JS, Dias M, Gadepalli R, Aggarwal A, Vedpathak M, Agrawal S, Pandit A, Nisheetha A, Kumar A, Bordoloi M, Shafi M, Shelar B, Balachandra SS, Damodar T, Masika MM, Mwaura P, Anzala O, Muthumani K, Sowdhamini R, Medigeshi GR, Roy R, Pattabiraman C, Krishna S, Sreekumar E. Immune profile and responses of a novel dengue DNA vaccine encoding an EDIII-NS1 consensus design based on Indo-African sequences. Mol Ther. 2022;30(5):2058-77. Epub 20220107. doi: 10.1016/j.ymthe.2022.01.013. PubMed PMID: 34999210; PMCID: PMC8736276.
  20. Rizvi ZA, Dalal R, Sadhu S, Binayke A, Dandotiya J, Kumar Y, Shrivastava T, Gupta SK, Aggarwal S, Tripathy MR, Rathore DK, Yadav AK, Medigeshi GR, Pandey AK, Samal S, Asthana S, Awasthi A. Golden Syrian hamster as a model to study cardiovascular complications associated with SARS-CoV-2 infection. Elife. 2022;11. Epub 20220111. doi: 10.7554/eLife.73522. PubMed PMID: 35014610; PMCID: PMC8794466.
  21. Hingankar N, Deshpande S, Das P, Rizvi ZA, Wibmer CK, Mashilo P, Ansari MY, Burns A, Barman S, Zhao F, Mukherjee S, Torres JL, Chattopadhyay S, Mehdi F, Sutar J, Rathore DK, Pargai K, Singh J, Sonar S, Jakhar K, Dandotiya J, Bhattacharyya S, Mani S, Samal S, Singh S, Kshetrapal P, Thiruvengadam R, Batra G, Medigeshi G, Ward AB, Bhatnagar S, Awasthi A, Sok D, Bhattacharya J. A combination of potently neutralizing monoclonal antibodies isolated from an Indian convalescent donor protects against the SARS-CoV-2 Delta variant. PLoS pathogens. 2022;18(4):e1010465. Epub 20220428. doi: 10.1371/journal.ppat.1010465. PubMed PMID: 35482816; PMCID: PMC9089897.
  22. Gupta A, Anand A, Jain N, Goswami S, Anantharaj A, Patil S, Singh R, Kumar A, Shrivastava T, Bhatnagar S, Medigeshi GR, Sharma TK; DBT India Consortium for COVID-19 Research. A novel G-quadruplex aptamer-based spike trimeric antigen test for the detection of SARSCoV-2. Mol Ther Nucleic Acids. 2021 Jun 24; 26:321-332. doi: 10.1016/j.omtn.2021.06.014. PMID: 34188971; PMCID: PMC8223116.
  23. Anantharaj A, Das SJ, Sharanabasava P, Lodha R, Kabra SK, Sharma TK and Medigeshi GR (2020) Visual Detection of SARS-CoV-2 RNA by Conventional PCR-Induced Generation of DNAzyme Sensor. Front. Mol. Biosci. 7:586254. doi: 10.3389/fmolb.2020.586254.