PROFILE PREVIEW

Dr. Lovejeet Kaur is trained in Biological Anthropology, with focus on nutrition and epi/genetics. Currently, she is working in the Department of Maternal and Child Health (MCH), THSTI, India and have research experience in the same domain for over a decade. Her research interest includes understanding the modifiable risk factors like nutrition and epigenetics of complex disorders. She has authored several articles on 1) vitamin, mineral and essential fatty acid deficiencies and their association with placental pathologies, and birth outcomes through maternal, placental & cord blood nutritional epi/genetics; and 2) inter/transgenerational effects of vitamin deficiencies on metabolic health outcomes.

Her current focus is on 1) Developmental Origins of Health and Disease (DOHaD) (in-utero programming) through peri-conception maternal and paternal nutrition, and 2) Understanding Postnatal-Lactational programming through breast milk nutrition. This research would help in exploring unique windows of opportunity within the ‘first 1000 days’ of life to intervene/tackle adverse health outcomes in mothers and infants. To investigate the same, she is employing multipronged approach, i.e. parallel work on human cohorts, animal models and cell lines. 

Orcid Link : orcid.org/0000-0002-2179-9865

Reviewer:Nutrition Journal; Frontiers in Nutrition; Plos one; Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy; International Journal of Women's Health; European Journal of Obstetrics & Gynecology and Reproductive Biology; International Journal of Health Governance; and Women’s Health, Annals of Medicine, Biomarkers in Medicine.

Member:

Life Member of Indian Society of Human Genetics (ISHG)

Life Member of Indian Society for Study of Reproduction and Fertility (ISSRF)

Life Member of United Indian Anthropology Forum (UIAF)

• Monangi, Nagendra K, Huan Xu, Yue-Mei Fan, Rasheeda Khanam, Waqasuddin Khan, Saikat Deb, Jesmin Pervin,  Price, JT, Kaur Lovejeet#, et al ..…Zarko Alfirevic, Abdullah H. Baqui, Bhatnagar, Shinjini, Jane E. Hirst,, Cathrine Hoyo, Fyezah Jehan, Laura Jelliffe-Pawlowski, Anisur Rahman, Daniel E. Roth, Sunil Sazawal, Jeffrey S. A. Stringer, Per Ashorn, Ge Zhang, Louis J. Muglia. “Maternal prenatal copper concentration as a biomarker for gestational duration and preterm birth: a multi-country meta-analysis”. The American Journal of Clinical Nutrition 119, no. 1 (2024): 221-231. (#first equal authorship)
• Singh, Praveen#, Lovejeet Kaur#, Subhoshree Ghose, Swati Varshney, Vislavath Jyothi, Sourav Ghosh, Pujitha Kommineni, Shamsudheen KV, Scaria Vinod, Sivasubbu Sridhar, Chandak Giriraj Ratan. "Maternal-Periconceptional Vitamin B12 Deficiency in Wistar Rats Leads to Sex-Specific Programming for Cardiometabolic Disease Risk in the Next Generation."  The Journal of Nutrition 153, no. 12 (2023): 3382-3396. (#first equal authorship).
• Kaur, Lovejeet, Deepali Sundrani, Kinjal Dave, Karuna Randhir, Savita Mehendale, Swati Bayyana, Kumaran Kalyanaraman, Giriraj R. Chandak, and Sadhana Joshi. "Hypoxia Inducible Factors (HIF1α and HIF3α) are differentially methylated in preeclampsia placentae and are associated with birth outcomes." Molecular and Cellular Biochemistry (2023): 1-10.
• Dave, Kinjal, Lovejeet Kaur, Deepali Sundrani, Preeti Sharma, Swati Bayyana, Savita Mehendale, Karuna Randhir, Giriraj R. Chandak, and Sadhana Joshi. "Association of placental fatty acid desaturase 2 (FADS2) methylation with maternal fatty acid levels in women with preeclampsia." Prostaglandins, Leukotrienes and Essential Fatty Acids 184 (2022): 102472.
• Talwar, Seerat, Sweta Prasad, Lovejeet Kaur, Mishra Jyoti, Puri Manju, Sachdeva MohinderPal, and Saraswathy Kallur Nava. "MTR, MTRR and CBS gene polymorphisms in recurrent miscarriages: A case control study from North India." Journal of Human Reproductive Sciences 15, no. 2 (2022): 191.
• Kaur, Lovejeet, Puri Manju, Sachdeva Mohinderpal, Mishra Jyoti & Saraswathy Kallur Nava*. Maternal one carbon metabolism and interleukin-10 &-17 synergistically influence the mode of delivery in women with Early Onset Pre-Eclampsia. Pregnancy Hypertens 24, 79–89 (2021).
• Dave, Kinjal, Lovejeet Kaur, Karuna N. Randhir, Savita S. Mehendale, Deepali P. Sundrani, Giriraj R. Chandak, and Sadhana R. Joshi*. Placental growth factor and Fms related tyrosine kinase-1 are hypomethylated in preeclampsia placentae. Epigenomics 13, 257–269 (2021).
• Vinay Singh Tanwar, Sourav Ghosh, Satish Sati, Subhoshree Ghose, Lovejeet Kaur, Kalle Anand Kumar, K. V. Shamsudheen, Ashok Patowary, Meghna Singh, V. Jyothi, Pujitha Kommineni, Sridhar Sivasubbu, Vinod Scaria, Manchala Raghunath, Rakesh Mishra, Giriraj Ratan Chandak & Shantanu Sengupta*. “Maternal vitamin B12 deficiency in rats alters DNA methylation in metabolically important genes in their offspring”. Mol Cell Biochem 468, 83–96 (2020).
• Mishra, Jyoti, Lovejeet Kaur, Suniti Yadav, Manju Puri, Mohinderpal Sachdeva, Saraswathy Kallur Nava*. MTHFR gene specific and global methylation patterns in normal pregnancy: A pilot study (India). Meta Gene 19, 203–206 (2019).
• Mishra, Jyoti, Seerat Talwar, Lovejeet Kaur, Chandiok Ketaki, Suniti Yadav, Mohinderpal Sachdeva, Lakshmy R, Manju Puri, Saraswathy Kallur Nava*.“Differential global and MTHFR gene specific methylation patterns in preeclampsia and recurrent miscarriages: A case-control study from North India”. Gene 704, 68–73 (2019).
• Philip James, Sara Sajjadi, Ashutosh Singh Tomar, Ayden Saffari, Caroline H D Fall, Andrew M Prentice, Smeeta Shrestha, Prachand Issarapu, Dilip Kumar Yadav, Lovejeet Kaur, Karen Lillycrop, Matt Silver, Giriraj R Chandak; EMPHASIS study group. “Candidate genes linking maternal nutrient exposure to offspring health via DNA methylation: a review of existing evidence in humans with specific focus on one-carbon metabolism”. Int J Epidemiol 47, 1910–1937 (2018).
• Mishra, Jyoti, Puri Manju, Lovejeet Kaur & Saraswathy Kallur Nava*. “Hyperhomocysteinemia and Folate Deficiency in Preterm Premature Rupture of Membranes: A Hospital Based Case Control Study (India)”. Journal of Womens Health, Issues and Care 7(4), (2018).
• Kaur, Lovejeet,Puri Manju, Saraswathy Kallur Nava*, Trivedi, S. S. & Sachdeva, M. P. “Recurrent pregnancy losses vis-à-vis anemia and vitamin (Folate/B12) imbalance”. International Journal of Health Governance 23, 281–287 (2018).
• Kaur, Lovejeet,Garg, Priyanka, Ghosh Pradeep. & Saraswathy Kallur Nava*. “Impaired Homocysteine Metabolism Associated with High Plasma Interleukin-17A Levels, a Pro-Atherogenic Marker, in an Endogamous Population of North India”. Ethn Dis 28, 525–530 (2018).
• Saraswathy Kallur Nava*, Lovejeet Kaur, Seerat Talwar, Jyoti Mishra, Suraj Huidrom, Sachdeva Mohinderpal, and Manju Puri.Methylenetetrahydrofolate Reductase Gene-specific Methylation and Recurrent Miscarriages: A Case- Control Study from North India. J Hum Reprod Sci 11, 142–147 (2018).
• Giriraj R. Chandak, Matt J. Silver, Ayden Saffari, Karen A. Lillycrop, Smeeta Shrestha, Sirazul Ameen Sahariah, Chiara Di Gravio, Gail Goldberg, Ashutosh Singh Tomar, Modupeh Betts, Sara Sajjadi, Lena Acolatse, Philip James, Prachand Issarapu, Kalyanaraman Kumaran, Ramesh D. Potdar, Andrew M. Prentice, Caroline H. D. Fall, the EMPHASIS study group, Lena Acolatse, Meraj Ahmed, Modupeh Betts, Giriraj R. Chandak, Harsha Chopra, Cyrus Cooper, Momodou K. Darboe, Chiara Di Gravio, Caroline H. D. Fall, Meera Gandhi, Gail R. Goldberg, Prachand Issarapu, Philip James, Ramatoulie Janha, Landing M. A. Jarjou, Lovejeet Kaur, Sarah H. Kehoe, Kalyanaraman Kumaran, Karen A. Lillycrop, Mohammed Ngum, Suraj S. Nongmaithem, Stephen Owens, Ramesh D. Potdar, Andrew M. Prentice, Ann Prentice, Tallapragada Divya Sri Priyanka, Ayden Saffari, Sirazul Ameen Sahariah, Sara Sajjadi, Harshad Sane, Smeeta Shrestha, Matt J. Silver, Ashutosh Singh Tomar, Kate A. Ward, Dilip Kumar Yadav & Chittaranjan S. Yajnik. “Protocol for the EMPHASIS study; epigenetic mechanisms linking maternal pre-conceptional nutrition and children’s health in India and Sub-Saharan Africa”. BMC Nutr 3, 81 (2017).
• Khot Vinita, Yadav Dileep, Shrestha Smeetha, Kaur Lovejeet, Deepali P. Sundrani, Preeti M. Chavan-Gautam, Savita S. Mehendale, Giriraj R. Chandak, and Sadhana R. Joshi*. Hypermethylated CpG sites in the MTR gene promoter in preterm placenta. Epigenomics 9, 985–996 (2017).
• Garg Priyanka, Kabita Salam, Sinha Ekta, Kalla Leena, Lovejeet Kaur, Saraswathy Kallur Nava*. “The association of non-HDL cholesterol with the presence of metabolic syndrome in North Indian subjects with and without CAD”. Ann Hum Biol 40, 111–115 (2013).
• Kaur Lovejeet, Puri Manju, Kaushik Shweta, Sachdeva Mohinderpal, Trivedi S Shubha, Saraswathy Kallur Nava*. “Genetic thromobophilia in pregnancy: a case-control study among North Indian women”. J Thromb Thrombolysis 35, 250–256 (2013).
• Puri Manju,Lovejeet Kaur, Walia K Gagandeep, Mukhopadhay Rupak, Sachdeva Mohinderpal, Saraswathy Kallur Nava*.  MTHFR C677T polymorphism, folate, vitamin B12 and homocysteine in recurrent pregnancy losses: a case control study among North Indian women. J Perinat Med 41, 549–554 (2013).

• International Travel grant (2018) from DST-SERB, GOI.
• Senior Research Fellowship by University Grants Commission (UGC), 2012.
• Junior Research Fellowship by University Grants Commission (UGC), 2010.

Selected presentations

• “Maternal Serum Trace Elements In Early Pregnancy And Their Association With Adverse Outcomes: Preliminary Results From GARBH-Ini Cohort, India” in 9th International Conference on Nutrition & Growth (2022)

• “Does pre-conceptional B12 supplementation alter cord blood B12 levels, birthweight and cord blood methylome? Preliminary results from PRIYA study” at Indian Society of Human Genetics Conference 2019, Kalyani, India.

• “Diet induced maternal vitamin B12 deficiency shows sex specific pattern of programming in Wistar rat offspring” at International Vitamin conference 2018, Sydney, Australia.

• “Immuno-amalgamation of NK cells and Tregs in a recurrent pregnancy loss patient: a clinical case report”, at Immunocon-40th Annual Conference of Indian Immunological Society (IIS), 2013.

• “Role of Vitamin B12 deficiency as a cause of anaemia and hyperhomocystenemia in women with Recurrent pregnancy losses”, in Genomeet 2013-Vitamin B12 and One Carbon Metabolism in Health and Disease: A Genomic Perspective, New Delhi, 8th to 10th March 2013.

• “MTHFR gene specific methyaltion in recurrent pregnancy losses”, in International Vitamin Conference on Advances and Controversies In B Vitamins and Choline, Leipzig, Germany, 2012.

• “Role of Creatinine and homocysteine in pre-eclmapsia”, at ISHG conference on Genomics and Community Health & International Symposium on Developmental and Complex Disorders, India, 2012.

Selected Workshops

• “Clinical Genomics” at CSIR-CCMB, Hyderabad, 11th March, 2018.

• “Mendelian Randomization and Epigenetic Cancer Epidemiology” at ACTREC, Mumbai, 2017.

• “Statistical Genomics and Genetics” at CR Rao AIMSCS, University of Hyderabad, 2015.

• Summer School on “Flow Cytometry” at UGC-Networking Resource Centre in Biological Sciences, School of Biological Sciences, Madurai Kamraj University, Madurai, India, 2012.

• “Flow Cytometry and Cell Sorting”, at CCMB-IICT, Hyderabad, 2012.