PROFILE PREVIEW

DR. DEEPJYOTI PAUL, Ph.D  

Research Scientist
+91-129-2876472  (9706452310)
deepjyoti [at] thsti [dot] res [dot] in
PhD

2024-Present: Research Scientist, Center for Microbial Reserach, THSTI, India 

2021–2024: MK Bhan Fellow, Department of Infection and Immunology, Translational Health Science and Technology Institute (THSTI), India.

2018: ISID/ESCMID Fellow, Cardiff University, UK

2013–2018:   PhD, Department of Microbiology, Assam University, India

Dr. Deepjyoti Paul, is an early carrier researcher working in the field of antimicrobial resistance at THSTI. His research is focused on understanding the mechanism of antimicrobial resistance and assessing the burden of AMR in Human and Environmental settings. It also targets to develop a One Health microbiological approach to combat the antimicrobial resistance in human, aquaand dairy settings. His research work also deals with the hospital and community infection control, mechanism of horizontal transmission of drugresistant determinants.

Research Interest:

          1. Engineer the bacterial genome to understandthe interactions between core and acquired genomes.

          2. Understand how the core and flexible bacterial genomework together to maintain the sustainability of functions that are crucial for virulence, genome repair, and dynamics of    GIs and other MGEs.

         3. To check the activity of biological compounds against reporter strains and identify hit molecules to restore the efficacy of existing antibiotics against drug resistant bacterial pathogens.

 

 2023

1.     Paul D, Chawla M, Ahrodia T, Narendrakumar L, Das B. Antibiotic Potentiation as a Promising Strategy to Combat Macrolide Resistance in Bacterial Pathogens. Antibiotics (Basel). 2023 Dec 11;12(12):1715. doi: 10.3390/antibiotics12121715.

2. Mehrotra T, Konar D, Pragasam AK, Kumar S, Jana P, Babele P, Paul D et al. Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis. PNAS (IF-12.779).

3. Deshamukhya C, Das BJ, Paul D Chanda D, Bhattacharjee A. Imipenem and meropenem influence the Las/Rhl quorum-sensing systems in clinical isolates of Pseudomonas aeruginosa, Lett Appl Microbiol (IF-2.813). 

4.    Narendrakumar L, Chakraborty M, Kumari S, Paul D and Das B. Beta-Lactam potentiators to re-sensitize resistant pathogens: Discovery, development, clinical use and the way forward, Front. Microbiol (IF-6.064). 

5.     Panwar S, Kumari S, Verma J,Bakshi S, Narendrakumar L, Paul D and Das B, Toxin-linked mobile genetic elements in major enteric bacterial pathogens, Gut Microbiome.

2022

  1. Wangkheimayum J, Paul D, Chanda DD, Singha KM, Bhattacharjee A. Elevated expression of rsmI can act as a reporter of aminoglycoside resistance inEscherichia coli using kanamycin as signal molecule. Infection Genetics and Evolution 2022; 98: 105229. (IF: 3.342)

2021

  1. Paul D, Anto N, Bhardwaj M, Prendiville A, Elangovan R, Bachmann TT, Chanda DD,Bhattacharjee A. Antimicrobial resistance in patients with suspected urinary tract infections in primary care in Assam, India. JAC Antimicrobial Resistance 2021; 14: 3(4).
  2. Deshamukhya C, Saikia R, Das BJ, Paul D, Dhar D, Bhattacharjee A. Expression of cupAgene cluster responsible for biofilm formation in Pseudomonas aeruginosa is enhanced against subinhibitory concentration of carbapenems. Gene Reports 2021; 26:101427.
  3. Paul D, Mazumder NB, Wangkheimayum J, Bhattacharjee A. Report of a carbapenemasegene blaIMP-4 in multi-drug resistant Escherichia coli from sewage water: A threat on clinical- environmental interphase. Indian Journal of Medical Microbiology 2021; 39(4):556-557 (IF-0.985).
  4. Choudhury NA, Paul D, Das BJ, Chanda DD, Bhattacharjee A. Adaptation of IncX3 plasmidencoding blaNDM−4 within a broad host range. Journal of Microbiology and Infectious Disease 2021; 11 (2):74-80.  
  5. Paul D, Dhar D, Chakravarty A, Bhattacharjee A, Transcriptional Analysis of IncFrepB-Mediated blaOXA−48-Positive Plasmid Characterized from Escherichia coli ST448. Microbial Drug Resistance 2021; 27:596-601. (IF-3.431)

 2020

  1. Paul D, Chanda DD, Chakravarty A, Bhattacharjee A. An insight into analysis and elimination of plasmids that encodes metallo-beta-lactamase in Pseudomonas aeruginosa. Journal of GlobalAntimicrobial Resistance2020; 21: 3-7. (IF-4.035).
  2. Wangkheimayum J, Majumder TD, Tapadar YB, Das BJ, Paul D, Dhar D, Chakravarty A, Bhattacharjee A.  Occurrence of diverse aminoglycoside modifying enzymes with co-existing extended-spectrum-β-lactamases within Enterobacteriaceae isolated in India. Journal of Global Antimicrobial Resistance 2020; 21: 369-374. (IF-4.035).
  3. Ingti B, Upadhyay S, Hazarika M, Khyriem AB, Paul D, Bhattacharya P, Joshi SR, Bora D, Dhar D, Bhattacharjee A. Distribution of carbapenem resistant Acinetobacter baumannii with blaADC-30 and induction of ADC-30 in response to beta-lactam antibiotics. Research in Microbiology 2020; 171: 128-133.(IF-2.651)
  4. Deshamukhya C, Das BJ, Chetri S, Paul D, Chanda DD, Banerjee T et al. Use of fluorescence
    foldscope as an effective tool for detection of biofilm formation in Pseudomosas aeruginosa.
    Indian Journal of Medical Microbiology; 2020; 38:397-400.(IF-0.985)
  5. Gajamer VR, Bhattacharjee A, Paul D, Ingti B, Sarkar A, Kapil J, Singh AK, Pradhan N, Tiwari HK. High prevalence of carbapenemase genes, AmpC genes and aminoglycosides resistance genes in extended spectrum β-lactamase positive uropathogens from Northern India. Journal of Global Antimicrobial Resistance 2020; 20:197-203.  (IF-4.035)
  6. Paul D, Chanda DD, Chakravarty A, Bhattacharjee A. An insight into analysis and elimination of plasmids that encodes metallo-beta-lactamases in Pseudomonas aeruginosa. Journal of Global Antimicrobial Resistance. 2020; 21: 3-7.(IF-IF-4.035)
  7. Paul D, Babenko D, Toleman MA.Human carriage of cefotaxime-resistant Escherichia coli in North-East India: an analysis of STs and associated resistance mechanisms. Journal of Antimicrobial Chemotherapy 2020; 75: 72-76. (IF-5.79)

2019

  1. Choudhury NA, Paul D, Das BJ, Dhar D, Bhattacharjee A. Adaptation of blaNDM through IncP plasmid within broad host range. Indian Journal of Medical Microbiology 2019; 37:527-30 (IF-0.985).
  2. Chetri S, Bhowmik D, Paul D, Pandey P, Chanda DD, Chakravarty A, Bora D, Bhattacharjee A. AcrAB-TolC efflux pump system plays a role in carbapenem non-susceptibility in Escherichia coli. BMC Microbiology 2019; 19:210 (IF-3.605)
  3. Bhowmik D, Chetri S, Paul D, Chanda DD, Bhattacharjee A. Detection and molecular typing of methicillin-resistant Staphyloccous aureus from north-eastern part of India. Medical Journal Armed Forces India 2019; 75: 86-89.

2018

  1. Paul D, Choudhury NA, Chakravarty A, Bhattacharjee A, Dhar D. IncX3 plasmid mediated occurrence of   blaNDM-4 within Escherichia coli ST448 from India. Journal of Infection and Public Health 2018; 11: 111-114 (IF-3.718).
  2. Paul D, Roy S, Elizabeth R, Dhar D, Chakravarty A, Bhattacharjee A. Transcriptional expression of PmrB and arnA within polymyxin-resistant nosocomial isolates of Pseudomonas aeruginosa from India. Journal of Microbiology and Infectious Disease 2018; 8: 61-68.
  3. Gajamer VR, Bhattacharjee A, Paul D, Jyotsna K, Arunabha S, Singh A, Pradhan N, Tiwari HK. The First Report of Phenotypic and Molecular Characterization of Extended-Spectrum Beta-Lactamase-Producing Uropathogens in Sikkim and Darjeeling Hills of India. Microbial Drug Resistance 2018; 24: doi.org/10.1089/mdr.2017.0159. (IF-3.431)
  4. Ingti B, Saikia P, Paul D, Maurya A, Dhar D, Chakravarty A, Bhattacharjee A.  Occurrence of blaCMY42 through IncI1 plasmid within multidrug-resistant Escherichia coli from a tertiary referral hospital of India. Journal of Global Antimicrobial Resistance 2018; 14: 78-82. (IF-4.035)
  5. Dasgupta N, Paul D, Dhar D, Chetri S, Chakravarty, Bhattacharjee A. Observation of a new pattern of mutations in gyrA and parC within Escherichia coli exhibiting fluroquinolone resistance. Indian Journal of Medical Microbiology 2018; 36: 131-135. (IF-0.985)
  6. Elizabeth R, Dhar D, Chakravarty A, Paul D, Chetri S, Bhowmik D, Wangkheimayum J, Bhattacharjee A. Association of glycerol kinase gene (glpK) with class 3 integrons: a novel cassette array within Escherichia coli. Indian Journal of Medical Microbiology 2018; 36: 104-107. (IF-0.985)
  7. Gajamer VR, Bhattacharjee A, Paul D, Deshamukhya C, Singh A, Pradhn N, Tiwari HK. Escherichia coli encoding blaNDM-5 associated with community-acquired urinary tract infections with unusual MIC creep-like phenomenon against imipenem. Journal of Global Antimicrobial Resistance 2018; 14:228-232. (IF-4.035)

 

2017

  1. Paul D, Ingti B, Bhattacharjee D, Maurya AP, Dhar D, Chakravarty A. Bhattacharjee A. An unusual occurrence of plasmid mediated blaOXA-23 carbapenemase in clinical isolates of Escherichia coli from India. International Journal of Antimicrobial Agents 2017; 49: 642-645. (IF- 5.283)
  2. Paul D, Wangkheimayum J, Dhar D, Nepram R, Chetri S, Bhowmik D, Chakravarty A, Bhattacharjee A. Occurrence of acquired 16s methyltransferase mediated aminoglycoside resistance in clinical isolates of enterobacteriaceae within a tertiary referral hospital of northeast India. Antimicrobial Agents and Chemotherapy 2017; 61: e01037-16 (IF-5.191)
  3. Paul D, Bhattacharjee A, Bhattacharjee D, Dhar D, Maurya AP, Chakravarty A. Transcriptional analysis of blaNDM-1 and copy number alteration under carbapenem stress. Antimicrobial Resistance and Infection Control 2017; 6:26: DOI 10.1186/s13756-017-0183-2. (IF-4.887)
  4. Paul D, Garg A, Bhattacharjee A. Occurrence of blaNDM-1 and blaNDM-5 in a tertiary referral hospital of north India.Microbial Drug Resistance 2017; DOI: 10.1089/mdr.2016.0124. (IF-3.431)
  5. Paul D, Bhattacharjee A, Ingti B, Choudhury NA, Maurya AP, Dhar D, Chakravarty A. Occurrence of blaNDM-7 within IncX3-type plasmid of Escherichia coli from India. Journal of Infection and Chemotherapy 2017; 23: 206-210(IF-2.211)
  6. Dasgupta N, Paul D, Dhar DC, Ingti B, Bhattacharjee D, Chakravarty A, Bhattacharjee A. An insight into selection specificity of quinolone resistance determinants within Enterobacteriaceae family. Journal of Global Antimicrobial Resistance 2017; 10: 40-46. (IF-4.035)
  7. Maurya AP, Dhar DC, Basumatary MK, Paul D, Ingti B, Choudhury D, Talukdar AD, Chakravarty A, Mishra S, Bhattacharjee A. Expansion of highly stable blaOXA-10 β-lactamase family within diverse host range among nosocomial isolates of Gram-negative bacilli within a tertiary referral hospital of Northeast India. BMC Research Notes 2017; 10:145.
  8. Ingti B, Paul D, Maurya AP, Bora D, Chanda DD, Chakravarty A, Bhattacharjee A. Occurrence of blaDHA‑1 mediated cephalosporin resistance in Escherichia coli and their transcriptional response against cephalosporin stress: a report from India. Annals of Clinical Microbiology and Antimicrobials. 2017; 16:13 DOI 10.1186/s12941-017-0189-x (IF-3.944)
  9.  Ingti B, Laskar MA, Choudhury S, Maurya AP, Paul D, Talukdar AD et al. Molecular and in silico analysis of a new plasmid-mediated AmpC β-lactamase (CMH-2) in clinical isolates of Klebsiella pneumoniae. Infection, Genetics and Evolution 2017; 48: 34–39. (IF-3.342)
  10. Ingti B, Paul D, Maurya AP, Bora D, Dhar DC, Chakravarty A, Bhattacharjee A. Expansion of plasmid mediated blaACT-2 among Pseudomonas aeruginosa associated with hospital infection and its transcriptional response under cephalosporin stress. Journal of Microbiology and Infectious Diseases 2017; 7 (2): 75-82.
  11. Sharma S, Bhowmik D, Chetri S,Paul D, Chanda DD, Chakravarty A, Bhattacharjee A.Tigecycline resistance among clinical isolates of Staphyloccous aureus from North-east India. Journal of Microbiology and Infectious Disease 2017; 7: 173-177.

 

2016

  1. Paul D, Maurya AP, Dhar D, Chakravarty A, Bhattacharjee A. Carriage of blaNDM-1 in Pseudomonas aeruginosa through multiple Inc type plasmids in a tertiary referral hospital of northeast India. Indian Journal of Medical Research 2016; 143: 826-829. (IF- 2.375)
  2. Paul D, Dhar Chanda D, Maurya AP, Mishra S, Chakravarty A, Sharma GD, Bhattacharjee A. Occurrence of co-existing blaVIM-2 and blaNDM-1 in clinical isolates of Pseudomonas aeruginosa from India. Annals of Clinical Microbiology and Antimicrobials 2016; 15:31 DOI 10.1186/s12941-016-0146-0. (IF-3.944)
  3. Choudhury D, Paul D, Ghosh SA, Talukdar AD, Choudhury MD, Maurya AP et al. Effect of single-dose carbapenem exposure on transcriptional expression of blaNDM-1 and mexA in Pseudomonas aeruginosa. Journal of Global Antimicrobial Resistance 2016; 7: 72–77. (IF-4.035)
  4. Singha P, Chanda DD,Maurya AP, Paul D, Chakravarty A, Bhattacharjee A. Distribution of Class II integrons and their contribution to antibiotic resistance within Enterobacteriaceae family in India.Indian Journal of Medical Microbiology2016; 34: 303-307. (IF-0.985)
  5. Choudhury D, Ghosh A, Dhar Chanda D, Das Talukdar A, Dutta Choudhury M, Paul D, et al. Premature Termination of MexR Leads to Overexpression of MexAB-OprM Efflux Pump in Pseudomonas aeruginosa in a Tertiary Referral Hospital in India. PLoS ONE 2016; 11(2):e0149156.doi:10.1371/journal.pone.0149156. (IF-3.240)

2015

  1. Paul D, Dhar Chanda D, Maurya AP, Mishra S, Chakravarty A, Sharma GD, Bhattacharjee A. Co Carriage of blaKPC-2 and blaNDM-1 in Clinical Isolates of Pseudomonas aeruginosa Associated with Hospital Infections from India. PLoS ONE 2015; 10(12): e0145823. doi:10.1371/journal.pone.0145823. (IF-3.240)
  2. Choudhury D, Das Talukdar A, Dutta Choudhury M, Maurya AP, Paul D, Dhar D, Chakravarty   A, Bhattacharjee A. Transcriptional Analysis of MexAB-OprM efflux pumps system of Pseudomonas aeruginosa and its role in carbapenem resistance in a tertiary referral hospital in India. PLoS ONE 2015; DOI:10.1371/journal.pone.0133842. (IF-3.240)

2014

  1. Mohammed A, Paul D, Bhattacharjee A. Carriage of quinolone resistance in faecal coliforms among healthy individuals: a study from northeast India. Indian Journal of Medical Microbiology 2014; 33:190-91. (IF-0.985)
  2. Sharma I, Laskar A,Paul D. Studies on Non-Cathethar Related Urinary Tract Infections from Assam, North-East India.Online International Interdisciplinary Research Journal 2014; 4:88-94.

2012

  1. Sharma I, Paul D. Prevalence of community acquired urinary tract infection in Silchar Medical College, Assam, India and its antimicrobial susceptibility profile. Indian Journal of Medical Science 2012; 66:273-9.

1. Paul D., Verma J., Banerjee A., Konar D., Das B. (2022) Antimicrobial Resistance Traits and Resistance Mechanisms in Bacterial Pathogens. In: Kumar V., Shriram V., Paul A., Thakur M. (eds) Antimicrobial Resistance. Springer, Singapore. https://doi.org/10.1007/978-981-16-3120-71. 

      2. Paul D., Das B. (2022) Gut Microbiome in the emergence of antibiotic-resistant bacterial pathogens. In: Das B., Singh V., (eds) Progress in Molecular Biology and Translational     Science; Human microbiome and Health Disease. Elsevier. https://doi.org/10.1016/bs.pmbts.2022.07.009. 

 

1. Bhabatosh Das, Paul D, Lekshmi N. Title: A Genetic Tool for Engineering the Genome of Bacteria and a method of preparing the same there of. Patent application no. 202411056506. Year: 2024.

2. Bhabatosh Das, Lekshmi N., Chawla M, Paul D. Title: Genetically engineered bacterial reporter strain and a method of preparing the same there of. Patent application no. 202411035814. Year:   2024.

3. Bhabatosh Das, Chawla M, Paul D, Mahajan D. Title: Discovery and development of aminoglycoside and chloramphenicol potentiators against multi-drug-resistant bacterial pathogens and their use thereof. Patent application no. 202411070536. Year: 2024.

 

 

 

 

Project 1: 

Title: "Understand the role of β-lactam antibiotics in the emergence and spread of multidrug resistant Klebsiella pneumoniae and Acinetobacter baumannii" ---Funded                              by Department of Biotechnology, Govt. of India. Funded by Department of Biotechnology, Govt. of India from 2021-2024. (PI)

Project 2:

Title: "Evaluation of novel dipstick-based molecular techniques for early detection of Gram-negative ESKAPE (KAPE) organism and antimicrobial resistance genes in burn wounds. Funded by ICMR, Govt. of India from 2024-2027. (Co-PI)

2024: Received the ECCMID outreach grant 

2023: Listed in the World rankings for Scientist by AD Scientist Index 2023. (AD Scientific Index 2023)

2022: Bill & Melinda Gates Foundation Professional Development Award 2022

2022: Travel Grant Award from 16th Asian Conference on Diarrhoeal Disease and Nutrition 2022

2021:      MK Bhan-Young Researcher Fellowship Program (YRFP) 2020-2021.

2021:      Listed in the World rankings for Scientist by AD Scientist Index 2021. (AD Scientific Index 2021)

2020:      Young Scientist Award 2020 from Microbiologists Society, India.

2020:      Recognition as COVID Warrior from Microbiologists Society, India & Hi-Media and Silchar Medical College and Hospital, Silchar

2019:      Received CSIR International Travel Support

2017:      Received ISID/ESCMID Fellowship 2017 in collaboration with Cardiff University, UK

2017:      International Travel Grant from SERB, Department of Science & Technology, Govt. of India

2016:      Recognized as prominent researcher in Antimicrobial Resistance (Scooping report on Antimicrobial resistance in India: Department of Biotechnology, Govt. of India &                     Research Councils UK)

2016:      Young Investigator Award from Bill & Melinda Gates Foundation

2016:      ESCMID Attendance Grant in International Conference on Contemporary Antimicrobial Research 2016

 

Reviewer:

Frontiers in Microbiology; IF: 5.64

Journal of Global Antimicrobial Resistance (Elsevier) IF: 4.035

Journal of Infection and Public Health (Elsevier) IF: 3.718

 

Invited Talks:

Invited as a speaker in the "Human Microbiome in Health & Diseases" 2023

Acted as a Resource person in the hands on workshop on “Next Generation Sequencing and Data Analysis” 2023 

Acted as a Resource person in the hands on training on “Bacterial Gene transfer mechanism” HTBGTM-2016) sponsored by Department of Biotechnology, Govt. of India.

Acted as a Resource person in the DBT, Govt. of India Sponsored two training programme on Bacterial Antimicrobial Sensitivity Test and Basics PCR Techniques organized by
Institutional Biotech Hub, S.S.College, India. 

Diploma:

Multilingual Office Automation and Financial Accounting

 

Conferences Attended:

2019: Attended and presented two (2) papers at ECCMID-2019 held in Amsterdam, Netherlands.

2017: Attended and presented paper at ISAAR and ICIC 2017 held in Busan, South Korea.2013-2018 Attended and presented in four (4) International and seven (7) National                  conferences in India

 

Dissertation Trainee

3. Miss Ritika Singh, Mohanlal Sukhadia University; Rajasthan (M.Sc Trainee). Year: 2024

2. Miss Sabiya Khan, CCSU, Meerut, Uttar Pradesh (M.Sc Trainee). Year: 2024

1. Mr. Akshat Jaiswal, Amity University, Rajasthan (B.Tech Trainee). Year: 2023

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