PROFILE PREVIEW

DR. SUSMITA CHAUDHURI, Ph.D.  

Associate Professor
+91-129-2876366 
susmita [at] thsti [dot] res [dot] in
Ph.D., National Institute of Cholera & Enteric Diseases, University of Calcutta.
M.Sc., University of Calcutta.
B.Sc., Presidency College, University of Calcutta.

Research Focus of the lab:

• Antimicrobial Resistance
• Life as a bacteria - active and dormant...and in a (bio)film
• Alternative diagnostic and therapeutic solutions for drug resistance microbial infections - MAbs, peptides, phages

Our present research interest is focused on anti-microbial resistance (AMR) by developing innovative diagnostics and drug delivery formulations for bacterial infections. We emphasize on a multi-pronged approach to tackle AMR with rapid, point of care diagnostics, improved formulations for controlling hospital acquired infections and developing alternative to antibiotics. With this long-term goal, we delve into in depth mechanistic studies of viable-but-non-culturable (VBNC) state of bacteria and microbes in biofilms relevant to bacterial species critical for human health.

Research Experience

  • Scientist D, Centre for Biodesign and Diagnostics, THSTI, 2018-2019

  • Scientist C, Centre for Biodesign and Diagnostics, THSTI, 2011-2018

  • Senior Scientist in Biopharmaceutical R&D, Panacea Biotec Ltd., New Delhi (2007-2011)

  • Postdoctoral Fellow in Department of Medical Microbiology & Immunology, University of Alberta, Canada (2005-2007)

  1. Chaitali Singhal…….. Susmita Chaudhuri. Label-free electrochemical aptasensor for detection of Acinetobacter baumannii: Unveiling the kinetic behaviour of reduced graphene oxide v/s graphene oxide. Electrochimica Acta. https://doi.org/10.1016/j.electacta.2024.144240.
  2. Venugopal S, ……. Chaudhuri S#, Mohapatra S#. Changes in antimicrobial resistance of Escherichia coli isolated from community associated urinary tract infection before and during the COVID-19 pandemic in India. Journal of Global Antimicrobial Resistance, 2024, https://doi.org/10.1016/j.jgar.2024.02.022 (#co-corresponding)
  3. Mehrotra T, ….., Chaudhuri S…., Das B. Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis. Proc Natl Acad Sci U S A. 2023;120(33):e2305465120. doi: 10.1073/pnas.2305465120.
  4. Kumar D,, ..…..Chaudhuri S. Colistin Potentiation in Multidrug Resistant Acinetobacter baumannii by a Non-cytotoxic Guanidine Derivative of Silver. Frontiers in Microbiology, 13, 1006604, 2023 
  5. Subasri, R*., …. Chaudhuri, S*., Prashant Garg*. Biofilm-inhibiting nanocomposite coatings on surgical sutures: durability and mechanistic insights. J Coat Technol Res 20, 377–392 (2023). https://doi.org/10.1007/s11998-022-00678-y (*Joint Corresponding)
  6. Mohapatra S, …, Chaudhuri S, …., Hari P; Investigators of CAUTION-ED STUDY (Community-acquired UTI & Emerging Drug Resistance). Genome profiling of uropathogenic E. coli from strictly defined community-acquired UTI in paediatric patients: a multicentric study, Antimicrob Resist Infect Control. 2023;12(1):36. doi: 10.1186/s13756-023-01233-z.
  7. Bhaskar, B., Patra, R., Soma Raju, K.R.C., Chaudhuri S*., Subasri R*. Biofilm inhibiting nanocomposite coatings on stainless steel surgical instruments: a possible strategy to prevent TASS. J Coat Technol Res 20, 559–572 (2023). https://doi.org/10.1007/s11998-022-00689-9  (*Joint Corresponding)
  8. Mohapatra S, Panigrahy R, Tak V, J V S, K C S,Chaudhuri S,….., Kant S. Prevalence and resistance pattern of uropathogens from community settings of different regions: an experience from India, Access Microbiol. 2022;4(2):000321. doi: 10.1099/acmi.0.000321
  9. Patra, R., …. Chaudhuri S*., Subasri R*. Biofilm inhibiting nanocomposite coatings—a promising alternative to combat surgical site infections. J Coat Technol Res 19, 1697–1711 (2022). https://doi.org/10.1007/s11998-022-00642-w   (*Joint Corresponding)
  10. Yadav M, …, Chaudhuri S. Formic acid, an organic acid food preservative, induces viable-but-non-culturable state, and triggers new Antimicrobial Resistance traits in Acinetobacter baumannii and Klebsiella pneumoniae, Front Microbiol. 2022;13:966207. doi: 10.3389/fmicb.2022.966207. (corresponding)
  11. Yadav M,.. Chaudhuri S*,  Mohapatra S* Virulence gene mutations as a differentiator of clinical phenotypes: Insights from community-acquired uropathogenic Escherichia coli. Microbiology. 2022.168:001161.  (*Joint Corresponding).
  12. Mohapatra S,…. Chaudhuri S…. Salve H. Antibiotic resistance of uropathogens among the community-dwelling pregnant and nonpregnant female: a step towards antibiotic stewardship. BMC Infectious Diseases. 2022. 22:939. https://doi.org/10.1186/s12879-022-07914-1
  13. Chopra A, …. S, Chaudhuri S, …, Patwardhan B. Randomized, Double Blind, Placebo Controlled, Clinical Trial to Study Ashwagandha Administration in Participants Vaccinated Against COVID-19 on Safety, Immunogenicity, and Protection With COVID-19 Vaccine-A Study Protocol, Front Med (Lausanne). 2022;9:888928. doi: 10.3389/fmed.2022.888928
  14. Dey A, …., Chaudhuri S*, Das A*. A combination therapy strategy for treating antibiotic resistant biofilm infection using a guanidinium derivative and nanoparticulate Ag(0) derived hybrid gel conjugate. Chem Sci. 2022;13(34):10103-10118. doi: 10.1039/d2sc02980d (*Joint corresponding)
  15. Kumar A, …., Chaudhuri S,Bhattacharyya S, Kumar N. Wuhan to World: The COVID-19 Pandemic. Front Cell Infect Microbiol. 2021;11:596201.
  16. Thiruvengadam R,….. Chaudhuri S…. Bhatnagar S. Longitudinal serology in SARS-CoV-2 infected individuals in India – a prospective cohort study. The American Journal of Tropical Medicine and Hygiene. 105(1), 2021, pp. 66–72
  17. Ansari S, …., Chaudhuri S, …, van Dongen MBM; Global AMR Insights Ambassador Network. The potential impact of the COVID-19 pandemic on global antimicrobial and biocide resistance: an AMR Insights global perspective. JAC Antimicrob Resist. 2021, 3(2):dlab038. doi: 10.1093/jacamr/dlab038.
  18. Chaudhuri S et. al., Essential laboratory diagnostic at each level of health laboratory services in South East Asia region. World Health Organization, 2020.
  19. Chaudhuri S* et. al., Comparative evaluation of SARS-CoV-2 IgG immunoassays in India. J Clin Virol, 2020, 24;131:104609.
  20. Das B, Chaudhuri S, Srivastava R, Nair GB, Ramamurthy T. Fostering research into antimicrobial resistance in India. BMJ. 2017 Sep 6;358:j3535. doi: 10.1136/bmj.j3535.
  21. Kumar N,  ……  Chaudhuri S. Exploring packaged microvesicle proteome composition of Chinese Hamster Ovary secretome. J Bioprocess Biotech. 2016. 6:274.
  22. Chaudhuri S, Maurya P, Kaur M, Tiwari A, Borth N, et al. (2015) Investigation of CHO Secretome: Potential Way to Improve Recombinant Protein Production from Bioprocess. J Bioprocess Biotech 5: 240 doi:10.4172/2155-9821.1000240
  23. Sharma C, .., Chaudhuri S, …, Tiwari A. A repertoire of high-affinity monoclonal antibodies specific to S. typhi: as potential candidate for improved typhoid diagnostic. Immunol Res. 2015. 
  24. S Chaudhuri, ... L J. Guilbert. Human cytomegalovirus interacts with TLR2 and CD14 on syncytiotrophoblasts to stimulate TNFα mRNA & apoptosis. Placenta. 2009. 30:994-1001.
  25. Chaudhuri S, ... Naik TN. Molecular epidemiology of HCV infection among acute and chronic liver disease patients in Kolkata, India. J Clin Virol. 2005 Jan;32(1):38-46.
  26. S. Das, V. Varghese, S. Chaudhuri, ...T. N. Naik.. Genetic variability of human rotavirus strains isolated from Eastern and Northern India. J Med Virol. 2004 Jan; 72 (1): 156-61.
  27. P. Barman, S. Ghosh, S. Das, V. Varghese, S. Chaudhuri, ...T.N. Naik. Sequencing and sequence analysis of VP7 and NSP5 genes reveal emergence of new genotype of bovine Group B rotaviruses in India. J Clin Microbiol. 2004 Jun; 42 (6): 2816-2818.
  28. Das S, Varghese V, Chaudhuri S, ... Naik TN. Emergence of Novel Human Group A Rotavirus G12 Strains in India. J Clin Microbiol 2003; 41: 2760-2762.
  29. Chowdhury A, Santra A, Chaudhuri S, ... Mazumdar DNG. Hepatitis C virus Infection in General Population: A Community Based Study in West Bengal, India. Hepatology 2003; 37: 802-809.
  30. Das S, Sen A, Uma G, Varghese V, Chaudhuri S, ....Naik TN. Genomic Diversity of Group A Rotavirus Strains Infecting Humans in Eastern India. J Clin Microbiol 2002; 40: 146-149.
  • Method of improving stability of recombinant protein product in CHO batch culture by selective removal of metalloproteinase rich exosomal fraction and uses thereof (2015)
  • Method of flow cytometry based rapid antimicrobial susceptibility testing and uses thereof (2017)
  • Discontinuous lateral flow test strip and method (2018)
  • Novel oxone-based sanitizer protect against toxic pathogens (2020)
  • Novel Fenton reagent-based sanitizer protect against toxic pathogens  (2020)
  • Biofilm inhibiting sol-gel composition for coating on substrates and process of preparing the same (2021)
  • Antimicrobial biofilm containing silver nanoparticles (2021)

1. Platform for enhanced pathogen detection for meningitis and sepsis: Rapid, portable, and

field-deployable diagnostics, ICMR

2. Platform for developing therapeutic monoclonal antibodies against Klebsiella pneumoniae , DBT

3. Inter-institutional School of diagnostic Innovation in Biodesign: A fellowship program for building next generation pool of diagnostic innovators and entrepreneur, DBT

4. 

·        Tie-BIRAC award for Women in Entrepreneurial Research, 2018.

·        NIH-Fogarty fellowship on Indo-US Framework Program on Global Health Innovation, sponsored by NIH-Fogarty International Centre for Microfluidics and Imaging training at Tufts University, Boston, USA, 2017.

·        Biotechnology Ignition Grant award for the development of ‘Rapid Point-of-care field deployable typhoid diagnostics’ by BIRAC, 2017.

·        MFN Strategic Training Programme fellowship, Perinatal Research Centre, University of Alberta, Canada, 2006-2007.

·        'Best Poster Award'; Poster entitled 'Molecular Epidemiology of HCV Infection among Acute and Chronic Liver Disease Patients in Kolkata'; VI-Sir Dorabji Tata Symposium on Viral Hepatitis at the Indian Institute of Science, Bangalore, India, on March 10-11, 2005.

·        National Scholarship (1997-98) of the Gov. of India on the result of B.Sc. (Zoology Hons.) Examination of Calcutta University.

·        'Sarasibala Chaudhuri' scholarship in the year 1997 for ranking 1st Class 2nd in Calcutta University in B.Sc. (Zoology Hons.) Exam.

Entrepreneurial Venture:

Co-Founder of Tritek Innovation Pvt. Ltd., based in THSTI Interim Incubation Centre, NCR Biotech Science Cluster, Faridabad.

DR. CHAITALI SINGHAL, MKB-YRFP FELLOW, THSTI

DR. MANISHA YADAV, SENIOR PROJECT ASSOCIATE, THSTI

MR. SUBHASH CHANDRA TANWAR, TECHNICAL OFFICER-I, MCTR

MS. SWETA PANDEY, PH.D STUDENT, THSTI

MR. DEEPAK KUMAR, PH.D STUDENT, THSTI

MS. POOJA JOSHI, PH.D STUDENT, THSTI

MS. JAYA, PHD STUDENT, THSTI

MS. SHRUTI GUPTA, PHD STUDENT, THSTI

MR. ANURAG TYAGI, PROJECT ASSOCIATE II, THSTI

MS. SUDARSHANA CHATTERJEE, PROJECT ASSOCIATE I, THSTI

MS. SAKSHI, TECHNICAL ASSISTANT, THSTI,

MR. RAJKUMAR DWIVEDI, LAB TECHNICIAN, THSTI

MR. CHANDAN, LAB TECHNICIAN, THSTI

MR. NIRANJAN KUMAR, LAB TECHNICIAN, THSTI

 

 

Copyright 2017 Translational Health Science and Technology Institute. All rights reserved. Designed & Maintained by IT, THSTI