Professor
+91-129-2876311
(+91-129-6525537)
gmedigeshi [at] thsti [dot] res [dot] in
Ph.D. from Georg-August University, Goettingen, Germany.
M.Sc. Biotechnology, University of Mysore, Karnataka, India.
B.Sc., Yuvaraja College, University Of Mysore, Karnataka, India.
https://www.indiascience.in/videos/covid-19-warriors-life-in-science-with-pallava-bagla-e
Present Research Interest
Our group primarily focuses on the host-pathogen interactions in human viral infections with particular focus on flaviviruses (Ex: Dengue virus) and respiratory viruses (Ex: Respiratory Syncytial Virus). Our primary objective is to generate basic knowledge in virus-host interactions that can be harnessed for vaccine and drug development. Focus areas include:
Collaborations
2013-2022
1. Das S, Singh J, Shaman H, Singh B, Anantharaj A, Sharanabasava P, Pandey R, Lodha R, Pandey AK, Medigeshi GR. Pre-existing antibody levels negatively correlate with antibody titers after a single dose of BBV152 vaccination. Nat Commun. 2022;13(1):3451. Epub 20220615. doi: 10.1038/s41467-022-31170-1. PubMed PMID: 35705548.
2. Medigeshi GR, Batra G, Murugesan DR, Thiruvengadam R, Chattopadhyay S, Das B, Gosain M, Ayushi, Singh J, Anbalagan A, Shaman H, Pargai K, Mehdi F, Das SJ, Kahlon N, Singh S, Kshetrapal P, Wadhwa N, Pandey AK, Bhatnagar S, Garg PK. Sub-optimal neutralisation of omicron (B.1.1.529) variant by antibodies induced by vaccine alone or SARS-CoV-2 Infection plus vaccine (hybrid immunity) post 6-months. EBioMedicine. 2022;78:103938. Epub 20220316. doi: 10.1016/j.ebiom.2022.103938. PubMed PMID: 35305396; PMCID: PMC8923830.
3. Anantharaj A, Gujjar S, Verma N, Khan NA, Shaman H, Sharanabasava P, Das A, Pandey R, Pandey AK, Medigeshi GR. Resolution of viral load in mild COVID-19 patients is associated with both innate and adaptive immune responses. J Clin Virol. 2022;146:105060. Epub 20211221. doi: 10.1016/j.jcv.2021.105060. PubMed PMID: 34971849; PMCID: PMC8687718.
4. Dhochak N, Agrawal T, Shaman H, Khan NA, Kumar P, Kabra SK, Medigeshi GR, Lodha R. Humoral cross-reactivity towards SARS-CoV-2 in young children with acute respiratory infection with low-pathogenicity coronaviruses. J Clin Virol Plus. 2022;2(1):100061. Epub 20220111. doi: 10.1016/j.jcvp.2022.100061. PubMed PMID: 35262034; PMCID: PMC8747779.
5. Thuluva S, Paradkar V, Turaga K, Gunneri S, Yerroju V, Mogulla R, Suneetha P, Kyasani M, Manoharan SK, Adabala S, Javvadi AS, Medigeshi G, Singh J, Shaman H, Binayke A, Zaheer A, Awasthi A, Singh C, Venkateshwar Rao A, Basu I, Akash Ashok Kumar K, Pandey AK. Immunogenic superiority and safety of Biological E’s CORBEVAX™ vaccine compared to COVISHIELD™ (ChAdOx1 nCoV-19) vaccine studied in a phase III, single blind, multicenter, randomized clinical trial. medRxiv. 2022:2022.03.20.22271891. doi: 10.1101/2022.03.20.22271891.
6. Thuluva S, Paradkar V, Turaga K, Gunneri S, Yerroju V, Mogulla R, Kyasani M, Manoharan SK, Medigeshi G, Singh J, Shaman H, Singh C, Venkateshwar Rao A. Selection of optimum formulation of RBD-based protein sub-unit covid19 vaccine (Corbevax) based on safety and immunogenicity in an open-label, randomized Phase-1 and 2 clinical studies. medRxiv. 2022:2022.03.08.22271822. doi: 10.1101/2022.03.08.22271822.
7. Thuluva S, Paradkar V, Gunneri S, Yerroju V, Mogulla R, Suneetha PV, Turaga K, Kyasani M, Manoharan SK, Adabala S, Javvadi AS, Medigeshi G, Singh J, Shaman H, Binayke A, Zaheer A, Awasthi A, Narang M, Nanjappa P, Mahantshetti N, Garg BS, Ravi MRN. Safety, tolerability and immunogenicity of Biological E’s CORBEVAX™ vaccine in children and adolescents: A Prospective, Randomised, Double-blind, Placebo controlled, Phase-2/3 Study. medRxiv. 2022:2022.04.20.22274076. doi: 10.1101/2022.04.20.22274076.
8. Thiruvengadam R, Awasthi A, Medigeshi G, Bhattacharya S, Mani S, Sivasubbu S, Shrivastava T, Samal S, Rathna Murugesan D, Koundinya Desiraju B, Kshetrapal P, Pandey R, Scaria V, Kumar Malik P, Taneja J, Binayke A, Vohra T, Zaheer A, Rathore D, Ahmad Khan N, Shaman H, Ahmed S, Kumar R, Deshpande S, Subramani C, Wadhwa N, Gupta N, Pandey AK, Bhattacharya J, Agrawal A, Vrati S, Bhatnagar S, Garg PK, Department of Biotechnology India Consortium for C-r. Effectiveness of ChAdOx1 nCoV-19 vaccine against SARS-CoV-2 infection during the delta (B.1.617.2) variant surge in India: a test-negative, case-control study and a mechanistic study of post-vaccination immune responses. Lancet Infect Dis. 2022;22(4):473-82. Epub 20211125. doi: 10.1016/S1473-3099(21)00680-0. PubMed PMID: 34838183; PMCID: PMC8616567.
9. Surendran H, Kumar S, Narasimhaiah S, Ananthamurthy A, Varghese PS, D'Souza GA, Medigeshi G, Pal R. SARS-CoV-2 infection of human-induced pluripotent stem cells-derived lung lineage cells evokes inflammatory and chemosensory responses by targeting mitochondrial pathways. J Cell Physiol. 2022. Epub 20220423. doi: 10.1002/jcp.30755. PubMed PMID: 35460571; PMCID: PMC9088312.
10. Singh J, Shaman H, Anantharaj A, Singh B, Pargai K, Kumar P, Chattopadhyay P, Devi P, Maurya R, Mishra P, Kahlon N, Pandey AK, Pandey R, Medigeshi GR. Infection with Omicron variant generates neutralizing antibodies to BA.1 and BA.2 sub-lineages and induces higher levels of cross-neutralizing antibodies to Delta variant. medRxiv. 2022:2022.01.28.22269990. doi: 10.1101/2022.01.28.22269990.
11. Sankaradoss A, Jagtap S, Nazir J, Moula SE, Modak A, Fialho J, Iyer M, Shastri JS, Dias M, Gadepalli R, Aggarwal A, Vedpathak M, Agrawal S, Pandit A, Nisheetha A, Kumar A, Bordoloi M, Shafi M, Shelar B, Balachandra SS, Damodar T, Masika MM, Mwaura P, Anzala O, Muthumani K, Sowdhamini R, Medigeshi GR, Roy R, Pattabiraman C, Krishna S, Sreekumar E. Immune profile and responses of a novel dengue DNA vaccine encoding an EDIII-NS1 consensus design based on Indo-African sequences. Mol Ther. 2022;30(5):2058-77. Epub 20220107. doi: 10.1016/j.ymthe.2022.01.013. PubMed PMID: 34999210; PMCID: PMC8736276.
12. Rizvi ZA, Dalal R, Sadhu S, Binayke A, Dandotiya J, Kumar Y, Shrivastava T, Gupta SK, Aggarwal S, Tripathy MR, Rathore DK, Yadav AK, Medigeshi GR, Pandey AK, Samal S, Asthana S, Awasthi A. Golden Syrian hamster as a model to study cardiovascular complications associated with SARS-CoV-2 infection. Elife. 2022;11. Epub 20220111. doi: 10.7554/eLife.73522. PubMed PMID: 35014610; PMCID: PMC8794466.
13. Misra P, Kant S, Guleria R, Rai S, Jaiswal A, Mandal S, Medigeshi GR, Ahmad M, Rahman A, Sangral M, Yadav K, Bairwa M, Haldar P, Kumar P. Antibody response to SARS-CoV2 among COVID-19 confirmed cases, and correlates with neutralizing assay in a subgroup of patients in Delhi National Capital Region, India. medRxiv. 2022:2022.05.17.22275193. doi: 10.1101/2022.05.17.22275193.
14. Mehdiratta K, Singh S, Sharma S, Bhosale RS, Choudhury R, Masal DP, Manocha A, Dhamale BD, Khan N, Asokachandran V, Sharma P, Ikeh M, Brown AC, Parish T, Ojha AK, Michael JS, Faruq M, Medigeshi GR, Mohanty D, Reddy DS, Natarajan VT, Kamat SS, Gokhale RS. Kupyaphores are zinc homeostatic metallophores required for colonization of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2022;119(8). doi: 10.1073/pnas.2110293119. PubMed PMID: 35193957; PMCID: PMC8872721.
15. Maheshwari D, Saini K, Singh P, Singla M, Nayak K, Aggarwal C, Chawla YM, Bajpai P, Kaur M, Gunisetty S, Eberhardt CS, Nyodu R, Moore K, Suthar MS, Medigeshi GR, Anderson E, Lodha R, Kabra SK, Ahmed R, Chandele A, Murali-Krishna K. Contrasting behavior between the three human monocyte subsets in dengue pathophysiology. iScience. 2022;25(6):104384. Epub 20220510. doi: 10.1016/j.isci.2022.104384. PubMed PMID: 35620424; PMCID: PMC9127603.
16. Hingankar N, Deshpande S, Das P, Rizvi ZA, Wibmer CK, Mashilo P, Ansari MY, Burns A, Barman S, Zhao F, Mukherjee S, Torres JL, Chattopadhyay S, Mehdi F, Sutar J, Rathore DK, Pargai K, Singh J, Sonar S, Jakhar K, Dandotiya J, Bhattacharyya S, Mani S, Samal S, Singh S, Kshetrapal P, Thiruvengadam R, Batra G, Medigeshi G, Ward AB, Bhatnagar S, Awasthi A, Sok D, Bhattacharya J. A combination of potently neutralizing monoclonal antibodies isolated from an Indian convalescent donor protects against the SARS-CoV-2 Delta variant. PLoS pathogens. 2022;18(4):e1010465. Epub 20220428. doi: 10.1371/journal.ppat.1010465. PubMed PMID: 35482816; PMCID: PMC9089897.
17. Thiruvengadam R, Awasthi A, Medigeshi G, Bhattacharya S, Mani S, Sivasubbu S, Shrivastava T, Samal S, Rathna Murugesan D, Koundinya Desiraju B, Kshetrapal P, Pandey R, Scaria V, Kumar Malik P, Taneja J, Binayke A, Vohra T, Zaheer A, Rathore D, Ahmad Khan N, Shaman H, Ahmed S, Kumar R, Deshpande S, Subramani C, Wadhwa N, Gupta N, Pandey AK, Bhattacharya J, Agrawal A, Vrati S, Bhatnagar S, Garg PK. Effectiveness of ChAdOx1 nCoV-19 vaccine against SARS-CoV-2 infection during the delta (B.1.617.2) variant surge in India: a test-negative, case-control study and a mechanistic study of post-vaccination immune responses. The Lancet Infectious Diseases. 2021. doi: https://doi.org/10.1016/S1473-3099(21)00680-0.
18. Panwar A, Wangchuk J, Kar M, Lodha R, Medigeshi GR. Dengue virus replication enhances labile zinc pools by modulation of ZIP8. Cellular Microbiology. 2021;23(12):e13395. doi: https://doi.org/10.1111/cmi.13395.
19. Misra P, Kant S, Guleria R, Rai SK, AIIMS WUSsto. Serological prevalence of SARS-CoV-2 antibody among children and young age (between age 2-17 years) group in India: An interim result from a large multi-centric population-based seroepidemiological study. medRxiv. 2021:2021.06.15.21258880. doi: 10.1101/2021.06.15.21258880.
20. Mehdiratta K, Singh S, Sharma S, Bhosale R, Choudhury R, Masal D, Manocha A, Dhamale BD, Khan N, A V, Sharma P, Ikeh M, Brown A, Parish T, Ojha A, Michael JS, Faruq M, Medigeshi G, Mohanty D, Re S, Natarajan V, Kamat S, Gokhale R. Kupyaphores are counter regulatory zinc homeostatic metallophores required for Mycobacterium tuberculosis colonization. Research Square; 2021.
21. Khan NA, Kar M, Panwar A, Wangchuk J, Kumar S, Das A, Pandey AK, Lodha R, Medigeshi GR. Oxidative stress specifically inhibits replication of dengue virus. J Gen Virol. 2021;102(4). Epub 2021/04/28. doi: 10.1099/jgv.0.001596. PubMed PMID: 33904816.
22. Haider M, Dholakia D, Panwar A, Garg P, Gheware A, Singh D, Singhal K, Burse SA, Kumari S, Sharma A, Ray A, Medigeshi GR, Sharma U, Prasher B, Mukerji M. Transcriptome analysis and connectivity mapping of Cissampelos pareira L. provides molecular links of ESR1 modulation to viral inhibition. Scientific reports. 2021;11(1):20095. Epub 2021/10/13. doi: 10.1038/s41598-021-99444-0. PubMed PMID: 34635729; PMCID: PMC8505412.
23. Gupta A, Anand A, Jain N, Goswami S, Ananthraj A, Patil S, Singh R, Kumar A, Shrivastava T, Bhatnagar S, Medigeshi GR, Sharma TK, Research DBTICfC-. A novel G-quadruplex aptamer-based spike trimeric antigen test for the detection of SARS-CoV-2. Mol Ther Nucleic Acids. 2021. Epub 2021/07/01. doi: 10.1016/j.omtn.2021.06.014. PubMed PMID: 34188971; PMCID: PMC8223116.
24. Aggarwal C, Saini K, Reddy ES, Singla M, Nayak K, Chawla YM, Maheshwari D, Singh P, Sharma P, Bhatnagar P, Kumar S, Gottimukkala K, Panda H, Gunisetty S, Davis CW, Kissick HT, Kabra SK, Lodha R, Medigeshi GR, Ahmed R, Murali-Krishna K, Chandele A. Immunophenotyping and Transcriptional Profiling of Human Plasmablasts in Dengue. Journal of virology. 2021;95(23):e0061021. Epub 20210915. doi: 10.1128/JVI.00610-21. PubMed PMID: 34523972.
25. Kumar P, Mukherjee A, Randev S, Medigeshi GR, Jat KR, Kapil A, Lodha R, Kabra SK. Epidemiology of Coronavirus Infection in Children and Their Impact on Lung Health: Finding From a Birth Cohort Study. Pediatr Infect Dis J. 2020;39(12):e452-e4. Epub 2020/09/15. doi: 10.1097/INF.0000000000002884. PubMed PMID: 32925544.
26. Kumar P, Mukherjee A, Randev S, Medigeshi GR, Jat KR, Kapil A, Lodha R, Kabra SK. Effect of acute respiratory infections in infancy on pulmonary function test at 3 years of age: a prospective birth cohort study. BMJ Open Respir Res. 2020;7(1). Epub 2020/02/23. doi: 10.1136/bmjresp-2019-000436. PubMed PMID: 32079606; PMCID: PMC7047475.
27. Khan NA, Singla M, Samal S, Lodha R, Medigeshi GR. Respiratory Syncytial Virus-Induced Oxidative Stress Leads to an Increase in Labile Zinc Pools in Lung Epithelial Cells. mSphere. 2020;5(3). Epub 2020/05/29. doi: 10.1128/mSphere.00447-20. PubMed PMID: 32461278; PMCID: PMC7253603.
28. ICMR COVID Study Group, Epidemiology C, Data Management Team, COVID Laboratory Team, VRDLN Team. Laboratory surveillance for SARS-CoV-2 in India: Performance of testing & descriptive epidemiology of detected COVID-19, January 22 - April 30, 2020. Indian Journal of Medical Research. 2020;151(5):424-37. doi: 10.4103/ijmr.IJMR_1896_20.
29. Ghose A, Bhattacharya S, Karthikeyan AS, Kudale A, Monteiro JM, Joshi A, Medigeshi G, Kang G, Bal V, Rath S, Shashidhara LS, John J, Chaudhuri S, Nagarkar A. Community prevalence of antibodies to SARS-CoV-2 and correlates of protective immunity in five localities in an Indian metropolitan city. medRxiv. 2020:2020.11.17.20228155. doi: 10.1101/2020.11.17.20228155.
30. Chaudhuri S, Thiruvengadam R, Chattopadhyay S, Mehdi F, Kshetrapal P, Shrivastava T, Desiraju BK, Batra G, Kang G, Bhatnagar S, Research DBTICfC-. Comparative evaluation of SARS-CoV-2 IgG assays in India. J Clin Virol. 2020;131:104609. Epub 2020/09/01. doi: 10.1016/j.jcv.2020.104609. PubMed PMID: 32866811; PMCID: PMC7444492.
31. Bosch I, Reddy A, de Puig H, Ludert JE, Perdomo-Celis F, Narvaez CF, Versiani A, Fandos D, Nogueira ML, Singla M, Lodha R, Medigeshi GR, Lorenzana I, Ralde HV, Gelvez-Ramirez M, Villar LA, Hiley M, Mendoza L, Salcedo N, Herrera BB, Gehrke L. Serotype-specific detection of dengue viruses in a nonstructural protein 1-based enzyme-linked immunosorbent assay validated with a multi-national cohort. PLoS neglected tropical diseases. 2020;14(6):e0008203. Epub 2020/06/25. doi: 10.1371/journal.pntd.0008203. PubMed PMID: 32579555; PMCID: PMC7351204 (www.e25bio.com), a company that develops point-of-care diagnostics for fever-causing infectious agents.
32. Arvind B, Medigeshi GR, Kapil A, Xess I, Singh U, Lodha R, Kabra SK. Aetiological agents for pulmonary exacerbations in children with cystic fibrosis: An observational study from a tertiary care centre in northern India. Indian J Med Res. 2020;151(1):65-70. Epub 2020/03/07. doi: 10.4103/ijmr.IJMR_1275_18. PubMed PMID: 32134016; PMCID: PMC7055172.
33. Anantharaj A, Gujjar S, Kumar S, Verma N, Wangchuk J, Khan NA, Panwar A, Kanakan A, A V, Vasudevan JS, Das A, Pandey AK, Pandey R, Medigeshi GR. Kinetics of viral load, immunological mediators and characterization of a SARS-CoV-2 isolate in mild COVID-19 patients during acute phase of infection. medRxiv. 2020:2020.11.05.20226621. doi: 10.1101/2020.11.05.20226621.
34. Anantharaj A, Das SJ, Sharanabasava P, Lodha R, Kabra SK, Sharma TK, Medigeshi GR. Visual Detection of SARS-CoV-2 RNA by Conventional PCR-Induced Generation of DNAzyme Sensor. Front Mol Biosci. 2020;7(444):586254. Epub 2021/01/12. doi: 10.3389/fmolb.2020.586254. PubMed PMID: 33425988; PMCID: PMC7793695.
35. Kar M, Nisheetha A, Kumar A, Jagtap S, Shinde J, Singla M, M S, Pandit A, Chandele A, Kabra SK, Krishna S, Roy R, Lodha R, Pattabiraman C, Medigeshi GR. Isolation and molecular characterization of dengue virus clinical isolates from pediatric patients in New Delhi. Int J Infect Dis. 2019;84S:S25-S33. Epub 2018/12/12. doi: 10.1016/j.ijid.2018.12.003. PubMed PMID: 30528666; PMCID: PMC6823047.
36. Kar M, Khan NA, Panwar A, Bais SS, Basak S, Goel R, Sopory S, Medigeshi GR. Zinc Chelation Specifically Inhibits Early Stages of Dengue Virus Replication by Activation of NF-kappaB and Induction of Antiviral Response in Epithelial Cells. Front Immunol. 2019;10(2347):2347. Epub 2019/10/22. doi: 10.3389/fimmu.2019.02347. PubMed PMID: 31632411; PMCID: PMC6779808.
37. Bais SS, Ratra Y, Khan NA, Pandey R, Kushawaha PK, Tomar S, Medigeshi G, Singh A, Basak S. Chandipura Virus Utilizes the Prosurvival Function of RelA NF-kappaB for Its Propagation. Journal of virology. 2019;93(14). Epub 2019/05/03. doi: 10.1128/JVI.00081-19. PubMed PMID: 31043529; PMCID: PMC6600208.
38. Medigeshi GR, Fink K, Hegde NR. Position Paper on Road Map for RNA Virus Research in India. Front Microbiol. 2018;9(1753):1753. Epub 2018/08/23. doi: 10.3389/fmicb.2018.01753. PubMed PMID: 30131779; PMCID: PMC6090158.
39. Ojha A, Nandi D, Batra H, Singhal R, Annarapu GK, Bhattacharyya S, Seth T, Dar L, Medigeshi GR, Vrati S, Vikram NK, Guchhait P. Platelet activation determines the severity of thrombocytopenia in dengue infection. Scientific reports. 2017;7:41697. Epub 2017/02/01. doi: 10.1038/srep41697. PubMed PMID: 28139770; PMCID: PMC5282509.
40. Kumar R, Singh N, Abdin MZ, Patel AH, Medigeshi GR. Dengue Virus Capsid Interacts with DDX3X-A Potential Mechanism for Suppression of Antiviral Functions in Dengue Infection. Front Cell Infect Microbiol. 2017;7(542):542. Epub 2018/02/02. doi: 10.3389/fcimb.2017.00542. PubMed PMID: 29387631; PMCID: PMC5776122.
41. Kumar P, Medigeshi GR, Mishra VS, Islam M, Randev S, Mukherjee A, Chaudhry R, Kapil A, Ram Jat K, Lodha R, Kabra SK. Etiology of Acute Respiratory Infections in Infants: A Prospective Birth Cohort Study. Pediatr Infect Dis J. 2017;36(1):25-30. Epub 2016/10/19. doi: 10.1097/INF.0000000000001359. PubMed PMID: 27753796.
42. Kar M, Singla M, Chandele A, Kabra SK, Lodha R, Medigeshi GR. Dengue Virus Entry and Replication Does Not Lead to Productive Infection in Platelets. Open Forum Infect Dis. 2017;4(2):ofx051. Epub 2017/05/12. doi: 10.1093/ofid/ofx051. PubMed PMID: 28491890; PMCID: PMC5420081.
43. Jain N, Oswal N, Chawla AS, Agrawal T, Biswas M, Vrati S, Rath S, George A, Bal V, Medigeshi GR. CD8 T cells protect adult naive mice from JEV-induced morbidity via lytic function. PLoS neglected tropical diseases. 2017;11(2):e0005329. Epub 2017/02/06. doi: 10.1371/journal.pntd.0005329. PubMed PMID: 28151989; PMCID: PMC5308832.
44. Bosch I, de Puig H, Hiley M, Carre-Camps M, Perdomo-Celis F, Narvaez CF, Salgado DM, Senthoor D, O'Grady M, Phillips E, Durbin A, Fandos D, Miyazaki H, Yen CW, Gelvez-Ramirez M, Warke RV, Ribeiro LS, Teixeira MM, Almeida RP, Munoz-Medina JE, Ludert JE, Nogueira ML, Colombo TE, Terzian ACB, Bozza PT, Calheiros AS, Vieira YR, Barbosa-Lima G, Vizzoni A, Cerbino-Neto J, Bozza FA, Souza TML, Trugilho MRO, de Filippis AMB, de Sequeira PC, Marques ETA, Magalhaes T, Diaz FJ, Restrepo BN, Marin K, Mattar S, Olson D, Asturias EJ, Lucera M, Singla M, Medigeshi GR, de Bosch N, Tam J, Gomez-Marquez J, Clavet C, Villar L, Hamad-Schifferli K, Gehrke L. Rapid antigen tests for dengue virus serotypes and Zika virus in patient serum. Sci Transl Med. 2017;9(409). Epub 2017/09/29. doi: 10.1126/scitranslmed.aan1589. PubMed PMID: 28954927; PMCID: PMC6612058.
45. Singla M, Kar M, Sethi T, Kabra SK, Lodha R, Chandele A, Medigeshi GR. Immune Response to Dengue Virus Infection in Pediatric Patients in New Delhi, India--Association of Viremia, Inflammatory Mediators and Monocytes with Disease Severity. PLoS neglected tropical diseases. 2016;10(3):e0004497. Epub 2016/03/18. doi: 10.1371/journal.pntd.0004497. PubMed PMID: 26982706; PMCID: PMC4794248.
46. Medigeshi GR, Kumar R, Dhamija E, Agrawal T, Kar M. N-Desmethylclozapine, Fluoxetine, and Salmeterol Inhibit Postentry Stages of the Dengue Virus Life Cycle. Antimicrob Agents Chemother. 2016;60(11):6709-18. Epub 2016/08/31. doi: 10.1128/AAC.01367-16. PubMed PMID: 27572397; PMCID: PMC5075077.
47. Kumar R, Agrawal T, Khan NA, Nakayama Y, Medigeshi GR. Identification and characterization of the role of c-terminal Src kinase in dengue virus replication. Scientific reports. 2016;6:30490. Epub 2016/07/28. doi: 10.1038/srep30490. PubMed PMID: 27457684; PMCID: PMC4960526.
48. Kakumani PK, Medigeshi GR, Kaur I, Malhotra P, Mukherjee SK, Bhatnagar RK. Role of human GRP75 in miRNA mediated regulation of dengue virus replication. Gene. 2016;586(1):7-11. Epub 2016/04/04. doi: 10.1016/j.gene.2016.03.053. PubMed PMID: 27039024.
49. Jenum S, Dhanasekaran S, Lodha R, Mukherjee A, Kumar Saini D, Singh S, Singh V, Medigeshi G, Haks MC, Ottenhoff TH, Doherty TM, Kabra SK, Ritz C, Grewal HM. Approaching a diagnostic point-of-care test for pediatric tuberculosis through evaluation of immune biomarkers across the clinical disease spectrum. Scientific reports. 2016;6:18520. Epub 2016/01/05. doi: 10.1038/srep18520. PubMed PMID: 26725873; PMCID: PMC4698754.
50. Chandele A, Sewatanon J, Gunisetty S, Singla M, Onlamoon N, Akondy RS, Kissick HT, Nayak K, Reddy ES, Kalam H, Kumar D, Verma A, Panda H, Wang S, Angkasekwinai N, Pattanapanyasat K, Chokephaibulkit K, Medigeshi GR, Lodha R, Kabra S, Ahmed R, Murali-Krishna K. Characterization of Human CD8 T Cell Responses in Dengue Virus-Infected Patients from India. Journal of virology. 2016;90(24):11259-78. Epub 2016/11/01. doi: 10.1128/JVI.01424-16. PubMed PMID: 27707928; PMCID: PMC5126381.
51. Kakumani PK, Rajgokul KS, Ponia SS, Kaur I, Mahanty S, Medigeshi GR, Banerjea AC, Chopra AP, Malhotra P, Mukherjee SK, Bhatnagar RK. Dengue NS3, an RNAi suppressor, modulates the human miRNA pathways through its interacting partner. The Biochemical journal. 2015;471(1):89-99. Epub 2015/07/30. doi: 10.1042/BJ20150445. PubMed PMID: 26221025.
52. Kakumani PK, Ponia SS, S RK, Sood V, Chinnappan M, Banerjea AC, Medigeshi GR, Malhotra P, Mukherjee SK, Bhatnagar RK. Role of RNA interference (RNAi) in dengue virus replication and identification of NS4B as an RNAi suppressor. Journal of virology. 2013;87(16):8870-83. Epub 2013/06/07. doi: 10.1128/JVI.02774-12. PubMed PMID: 23741001; PMCID: PMC3754049.
53. Haridas V, Rajgokul KS, Sadanandan S, Agrawal T, Sharvani V, Gopalakrishna MV, Bijesh MB, Kumawat KL, Basu A, Medigeshi GR. Bispidine-amino acid conjugates act as a novel scaffold for the design of antivirals that block Japanese encephalitis virus replication. PLoS neglected tropical diseases. 2013;7(1):e2005. Epub 2013/01/26. doi: 10.1371/journal.pntd.0002005. PubMed PMID: 23350007; PMCID: PMC3547849.
54. Agrawal T, Sharvani V, Nair D, Medigeshi GR. Japanese encephalitis virus disrupts cell-cell junctions and affects the epithelial permeability barrier functions. PloS one. 2013;8(7):e69465. Epub 2013/07/31. doi: 10.1371/journal.pone.0069465. PubMed PMID: 23894488; PMCID: PMC3722119.
55. Agrawal T, Schu P, Medigeshi GR. Adaptor protein complexes-1 and 3 are involved at distinct stages of flavivirus life-cycle. Scientific reports. 2013;3:1813. Epub 2013/05/10. doi: 10.1038/srep01813. PubMed PMID: 23657274; PMCID: PMC3648799.
Prior to 2013
1. Medigeshi GR. Mosquito-borne flaviviruses: overview of viral life-cycle and host–virus interactions. Future Virology. 2011;6(9):1075-89. doi: 10.2217/fvl.11.85.
2. Wertheimer AM, Uhrlaub JL, Hirsch A, Medigeshi G, Sprague J, Legasse A, Wilk J, Wiley CA, Didier P, Tesh RB, Murray KO, Axthelm MK, Wong SW, Nikolich-Zugich J. Immune response to the West Nile virus in aged non-human primates. PloS one. 2010;5(12):e15514. Epub 2010/12/15. doi: 10.1371/journal.pone.0015514. PubMed PMID: 21151986; PMCID: PMC2996299.
3. Medigeshi GR, Hirsch AJ, Brien JD, Uhrlaub JL, Mason PW, Wiley C, Nikolich-Zugich J, Nelson JA. West nile virus capsid degradation of claudin proteins disrupts epithelial barrier function. Journal of virology. 2009;83(12):6125-34. Epub 2009/04/17. doi: 10.1128/JVI.02617-08. PubMed PMID: 19369347; PMCID: PMC2687390.
4. Goodman AG, Fornek JL, Medigeshi GR, Perrone LA, Peng X, Dyer MD, Proll SC, Knoblaugh SE, Carter VS, Korth MJ, Nelson JA, Tumpey TM, Katze MG. P58(IPK): a novel "CIHD" member of the host innate defense response against pathogenic virus infection. PLoS pathogens. 2009;5(5):e1000438. Epub 2009/05/23. doi: 10.1371/journal.ppat.1000438. PubMed PMID: 19461876; PMCID: PMC2677460.
5. Medigeshi GR, Krikunova M, Radhakrishnan K, Wenzel D, Klingauf J, Schu P. AP-1 membrane-cytoplasm recycling regulated by mu1A-adaptin. Traffic. 2008;9(1):121-32. Epub 2007/11/09. doi: 10.1111/j.1600-0854.2007.00672.x. PubMed PMID: 17988225.
6. Medigeshi GR, Hirsch AJ, Streblow DN, Nikolich-Zugich J, Nelson JA. West Nile virus entry requires cholesterol-rich membrane microdomains and is independent of alphavbeta3 integrin. Journal of virology. 2008;82(11):5212-9. Epub 2008/04/04. doi: 10.1128/JVI.00008-08. PubMed PMID: 18385233; PMCID: PMC2395215.
7. Medigeshi GR, Lancaster AM, Hirsch AJ, Briese T, Lipkin WI, Defilippis V, Fruh K, Mason PW, Nikolich-Zugich J, Nelson JA. West Nile virus infection activates the unfolded protein response, leading to CHOP induction and apoptosis. Journal of virology. 2007;81(20):10849-60. Epub 2007/08/10. doi: 10.1128/JVI.01151-07. PubMed PMID: 17686866; PMCID: PMC2045561.
8. Scott GK, Fei H, Thomas L, Medigeshi GR, Thomas G. A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking. The EMBO journal. 2006;25(19):4423-35. Epub 2006/09/16. doi: 10.1038/sj.emboj.7601336. PubMed PMID: 16977309; PMCID: PMC1589982.
9. Hirsch AJ, Medigeshi GR, Meyers HL, DeFilippis V, Fruh K, Briese T, Lipkin WI, Nelson JA. The Src family kinase c-Yes is required for maturation of West Nile virus particles. Journal of virology. 2005;79(18):11943-51. Epub 2005/09/06. doi: 10.1128/JVI.79.18.11943-11951.2005. PubMed PMID: 16140770; PMCID: PMC1212629.
10. Medigeshi GR, Schu P. Characterization of the in vitro retrograde transport of MPR46. Traffic. 2003;4(11):802-11. Epub 2003/11/18. doi: 10.1034/j.1600-0854.2003.00136.x. PubMed PMID: 14617361.
11. Roy N, Guruprasad MR, Kondaiah P, Mann EA, Giannella RA, Visweswariah SS. Protein kinase C regulates transcription of the human guanylate cyclase C gene. European journal of biochemistry / FEBS. 2001;268(7):2160-71. Epub 2001/03/30. doi: 10.1046/j.1432-1327.2001.02101.x. PubMed PMID: 11277940.
12. Meyer C, Eskelinen EL, Guruprasad MR, von Figura K, Schu P. Mu 1A deficiency induces a profound increase in MPR300/IGF-II receptor internalization rate. Journal of cell science. 2001;114(Pt 24):4469-76. Epub 2002/01/17. PubMed PMID: 11792812.
13. Vijayachandra K, Guruprasad M, Bhandari R, Manjunath UH, Somesh BP, Srinivasan N, Suguna K, Visweswariah SS. Biochemical characterization of the intracellular domain of the human guanylyl cyclase C receptor provides evidence for a catalytically active homotrimer. Biochemistry. 2000;39(51):16075-83. Epub 2000/12/22. doi: 10.1021/bi0013849. PubMed PMID: 11123935.
|
Publication ‘title’ and date of publication | Patents filed ‘title’ and date fo filing | Patents granted ‘title’ and date | Remarks, if any | |
| 1 |
Bispidine-amino acid conjugates act as a novel scaffold for the design of antivirals that block Japanese encephalitis virus replication. PLoS neglected tropical diseases. 2013;7(1):e2005. |
Japanese enchepalitis Virus inhibitor Date of filing: 23rd Nov, 2011 |
Patent No. 361663 !7th March 2021 |
||
| 2 | Visual Detection of SARS-CoV-2 RNA by Conventional PCR-Induced Generation of DNAzyme Sensor. Front Mol Biosci. 2020;7(444):586254. | A DNAzyme-based colorimetric detection of SARS-CoV-2 and its uses thereof | TEMP/E-1/22576/2020-DEL |
Nature Communications volume 13, Article number: 3451 (2022)
https://www.nature.com/articles/s41467-022-31170-1
Accepting PhD students with CSIR-UGC/DBT/ICMR fellowships
Dr. Balwant SinghJunior Research Scientist, Clinical and Cellular Virology, THSTI (Dec 2021 - present)
Senior Technical Officer, Bioassay Laboratory, THSTI (Dec 2020 – Dec 2021)
PhD, Department of Biosciences and Bioengineering, IIT Guwahati (2020)
MPhil, Department of Biotechnology, HPU Shimla (2012)
MSc, HPU Shimla (2011), BSc, HPU Shimla (2009)
Email: balwant@thsti.res.in
Broad areas of Research
1. Dengue virus characterization to understand its genetic diversity, evolution and pathogenicity for establishing therapeutic strategies
2. Expression and production strategies to develop recombinant viral antigens for functional assays
Amresh Kumar Singh
Lab Technician – 2011 – Present
B.A. (Hons) in History, Bihar University
Email: ccvlab@thsti.res.in
I have been working in research labs since 1998 and in CCV lab since 2011 and play an important role in keeping our lab functional and productive. I take care of all the day-to-day research requirements of the lab.
Project Associate – II (June 2021 –Present)
M.Sc. in Lifesciences (2019) from Central University of South Bihar
Email: poojashashi@thsti.res.in
Recent outbreaks of several pathogenic viruses like Ebola, Dengue , Zika , and now SARS-CoV-2 make virology research exciting. There is conceivability of new viruses emerging that can infect humans, and demanding regular research about these viruses to develop treatment methodologies. I am contributing to establishing platform technologies to support prophylactic and therapeutic strategies for Dengue-Discovery to proof-of-concept.
I have always been a very creative person and find it relaxing to indulge in craft activities.
Shivam SinghPh.D. Student (April 2021 – present)
M.Sc. Biotechnology (2019) from Central University of Rajasthan
Email: shivamsingh@thsti.res.in
I was always fascinated with viral diseases and to think about the ways we could tackle them. The SARS-CoV-2 pandemic has highlighted the multipronged approach one needs to take to do so. With the urge to learn more in this field, I joined CCV lab in April 2021. Prior to this, I worked at the All India Institute of Medical Sciences (AIIMS), New Delhi as a Junior research fellow. Currently, I am working on Respiratory Syncytial virus.
My hobbies are playing badminton, volleyball, and travelling.
Sonia TewatiaB.Sc. Medical Laboratory Technology (2021), Himalayan University
Diploma in Medical Laboratory Technology (2017) from Haryana State Board of Technical Education
Email: sonia.na@thsti.res.in
I am involved in assay development for dengue vaccines and serosurveys since July 2020
Rohit SinghPh.D. student (February 2022–Present)
M.Sc. in Molecular Medical Microbiology (2020) from Indian Institute of Technology, Kharagpur
Email: rohitsingh@thsti.res.in
I began my journey in the field of biological sciences with an internship in a Forensic biology laboratory wherein I saw science in action and its far-reaching effects on society. During my undergraduate and postgraduate coursework, I developed a keen interest in infectious diseases, immunology, and epidemiology, which encouraged me to join the CCV lab. When I am not in the lab, I like to read novels, cook, dance, travel, and watch movies.
Ph.D. Student – 2020 - Present
M.Sc. in Biotechnology from Visva-Bharati, West Bengal (India)
B.Sc. in Life Science from University of Delhi, Delhi (India)
Viruses are the simplest non-living creatures in the world which are able to infect diverse groups of living organisms. My passion is to explore the simplicity of virus as an organism and its complex interactions with the host. Currently, I am trying to understand the role of immune evasion strategies of dengue virus.
Apart from academia, I love to play cricket and listening music.
Diwakar RathourPh.D. Student- 2021- Present
M.Phil. in Zoology from Dr. Bhimrao Ambedkar University, Agra
M.SC. in Zoology from Dr. Bhimrao Ambedkar University, Agra
B.SC. in Biology from Dr. Bhimrao Ambedkar University, Agra
My work focuses on understanding innate and adaptive immune responses elicited during dengue infection.
I like to play chess and cricket.
Rinki Kumar (2012 – 2018)
Currently working as Post-doctoral fellow
Penn State Health
Milton S. Hershey Medical Center, Hershey, PA 17033, USA
Bond & Bradley Award for Outstanding Postdoctoral Scholar - Runner Up
Meenakshi Kar (2013-2019)Current Position: Grants Advisor, India Alliance
Naseem Ahmed Khan (2014-2020)Current Position: Auro Vaccines Pvt. Ltd.., (A subsidiary of Aurobindo Pharma), Hyderabad
Aleksha Panwar (2016-2022)
Current Position: Reddy's Laboratories, Hyderabad
