PROFILE PREVIEW

 Currently, my lab is working to understand the genome and genetics of microbial community associated with (a) Gastroenteritis (b) Sepsis (c) Term   and preterm birth.

(a)   Genomics of bacterial pathogens: We are investigating the (i) genome compositions and functions of  bacterial pathogens associated with SEPSIS, DIARRHOEA and GASTRIC CANCER (ii) Emergence of antimicrobial resistant bacterial pathogens. In addition, our lab is actively involved in engineering bacterial genome for developing reporter strains to screen compound library and identify hit molecules that will help to restore the efficacy of existing antibiotics against drug resistant bacterial pathogens, specially Gram-negative ESKAPE pathogens.

Vision: Identify potential target and hit molecules for developing antibiotic potentiators.

(b) Alternative to Antibiotics: Extensive drug-resistant bacterial pathogens drastically reduce the efficacy of most of the routinely used antibiotics in the health sector. Antimicrobial resistant crisis is a urgent situation that needs immediate attention. An alternative to antibiotics to tackle drug-resistant bacterial pathogens is a potential option. We are working on the discovery and development of bacteriophage-based biotherapeutics to treat extensively drug-resistant bacterial pathogens responsible for sepsis, urinary tract infections, respiratory tract infections, and gastro-intestinal tract infections. We have isolated hundreds of bacteriophages that can eliminate Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Vibrio cholerae, and Neisseria gonorrhoeae from the infection sites. Currently, we are developing effective bacteriophage coktails to use it against blood-stream infections, respiratory tract infections, and gastro-intestinal tract infections.

Vision: Develop an effective phage cocktail to treat extensive drug-resistant bacterial infections.

(c)  Live Biotherapeutics Development: We are focused on isolating and characterizing human-associated gut and reproductive tract microbiota to develop live biotherapeutics targeting metabolic diseases such as obesity and MASLD. Our primary goal is to decode the genomic sequences of these microbiota, predict the therapeutic potential of various peptides, and validate our findings in appropriate animal models. Additionally, we are engineering the genomes of commensal gut and reproductive tract microbiota to produce therapeutic peptides derived from human or microbial origins.

Vision: To develop recombinant live biotherapeutics for the treatment of obesity and MASLD.

Complete publications link: https://www.ncbi.nlm.nih.gov/myncbi/bhabatosh.das.1/bibliography/public/

 

Selected Publications:

1.     Paul D, Verma J, Kumar S, Talukdar D, Jana P, Narendrakumar L, Kumar R, Tanwar S, Gosain M, Porey Karmakar S, Pareek M, Mani S, Chaudhuri S, Kshetrapal P, Wadhwa N, Bhatnagar S, Garg PK and Das B (2024) A rapid point-of-care population-scale dipstick assay to identify and differentiate SARS-CoV-2 variants in COVID-19-positive patients. Front. Microbiol. 15:1459644. doi: 10.3389/fmicb.2024.1459644

2.     Talukdar D, Sarkar M, Ahrodia T, Kumar S,De D, Nath S, Jana1 P, Verma J, Mehta O, Kothidar A, Yodhaanjali Y, Sharma K, Bakshi S, Singh U, Kshetrapal P, Wadhwa N, Thiruvengadam R, GARBH-Ini study group, Nair GB, Bhatnagar S, Mukherjee S, Das B. (2024) Previse preterm birth in early pregnancy through vaginal microbiome signatures using metagenomics and dipstick assays. Volume 27, Issue 11111238November 15, 2024 iScience.

3.     Gaur KK, Asuru TR, Srivastava M, Singh N, Purushotham N, Poojary B, Das B, Bhattacharyya S, Asthana S, Guchhait P. 7D, a small molecule inhibits dengue infection by increasing interferons and neutralizing-antibodies via CXCL4:CXCR3:p38:IRF3 and Sirt1:STAT3 axes respectively. EMBO Mol Med. 2024 Oct;16(10):2376-2401. doi: 10.1038/s44321-024-00137-8. Epub 2024 Sep 16. PubMed PMID: 39284947.

4.     Deka A, Kumar N, Basu S, Chawla M, Bhattacharya N, Ali SA, Bhawna, Madan U, Kumar S, Das B, Sengupta D, Awasthi A, Basak S. Non-canonical NF-κB signaling limits the tolerogenic β-catenin-Raldh2 axis in gut dendritic cells to exacerbate intestinal pathologies. EMBO J. 2024 Sep;43(18):3895-3915. doi: 10.1038/s44318-024-00182-6. Epub 2024 Jul 25. PubMed PMID: 39060515; PubMed Central PMCID: PMC11405688.

5.     Arunan B, Talukdar D, Swain S, Varadarajan A, Sarda R, Singh G, Nischal N, Soneja M, Bakshi S, Jana P, Tanwar S, Sikka K, Verma H, Subramanian A, Xess I, Wig N, Das B, Ray A. Metagenomic insights into fungal community composition of the nasopharyngeal region of COVID-19 associated mucormycosis patients from India. J Med Virol. 2024 Apr;96(4):e29601. doi: 10.1002/jmv.29601. PubMed PMID: 38597375.

6.     Wadhwa K, Malik S, Balaji S, Thiruvengadam R, Bashyam MD, Bhattacharya PK, Behera B, Bhardwaj P, Biswas NK, Das A, Dey A, Dhotre D, Dias M, Dubey P, Dutta S, Gadepalli R, Gosain M, Goud KI, Gupta NK, Gupta N, Jana P, Jena D, John E, Karunanidhi A, Khan SMS, Khattar S, Paul APK, Kumar S, Maitra A, Modi N, Moorthy M, Nagaraj S, Palakodeti D, Pandey AK, Pandey A, Raghav SK, Ramasubban S, Raghavan S, Harikrishnan S, Krishnamoorthy S, Selvamurugan S, Sardana R, Shouche Y, Singh A, Singh AK, Ramasubramaniyan V, Yadav M, Zahoor D, Narreddy S, Bhatnagar S, Wadhwa N, Das B, Garg PK. Correlation of severity & clinical outcomes of COVID-19 with virus variants: A prospective, multicentre hospital network study. Indian J Med Res. 2024 Jan 1;159(1):91-101. doi: 10.4103/ijmr.ijmr_1041_23. Epub 2024 Mar 4. PubMed PMID: 38344919; PubMed Central PMCID: PMC10954099.

7.     Purohit A, Kandiyal B, Kumar S, Pragasam AK, Kamboj P, Talukdar D, Verma J, Sharma V, Sarkar S, Mahajan D, Yadav R, Ahmed R, Nanda R, Dikshit M, Banerjee SK, Shalimar, Das B. Collinsella aerofaciens linked with increased ethanol production and liver inflammation contribute to the pathophysiology of NAFLD. iScience. 2024 Feb 16;27(2):108764. doi: 10.1016/j.isci.2023.108764. eCollection 2024 Feb 16. PubMed PMID: 38313048; PubMed Central PMCID: PMC10837629.

8.     Saha M, Pragasam AK, Kumari S, Verma J, Das B, Bhadra RK. Genomic and functional insights into antibiotic resistance genes floR and strA linked with the SXT element of Vibrio cholerae non-O1/non-O139. Microbiology (Reading). 2024 Jan;170(1). doi: 10.1099/mic.0.001424. PubMed PMID: 38180462; PubMed Central PMCID: PMC10866021.

9.  Kamboj K, Bhardwaj N, Das B, (2024) Unraveling genetic variability in antimicrobial resistance among intracellular and extracellular bacteria. Sci. and Cult. 90 (11–12):432-444. DOI: https://doi.org/10.36094/sc.v89.2024.

 

10.     Paul D, Chawla M, Ahrodia T, Narendrakumar L, Das B. Antibiotic Potentiation as a Promising Strategy to Combat Macrolide Resistance in Bacterial Pathogens. Antibiotics (Basel). 2023 Dec 11;12(12). doi: 10.3390/antibiotics12121715. Review. PubMed PMID: 38136749; PubMed Central PMCID: PMC10740890.

11.  Pavan S, Gorthi SP, Prabhu AN, Das B, Mutreja A, Vasudevan K, Shetty V, Ramamurthy T, Ballal M. Dysbiosis of the Beneficial Gut Bacteria in Patients with Parkinson's Disease from India. Ann Indian Acad Neurol. 2023 Nov-Dec;26(6):908-916. doi: 10.4103/aian.aian_460_23. Epub 2023 Oct 31. PubMed PMID: 38229613; PubMed Central PMCID: PMC10789430.

12.  Saikrishna K, Talukdar D, Das S, Bakshi S, Chakravarti P, Jana P, Karmakar S, Wig N, Das B, Ray A. Study on Effects of Probiotics on Gut Microbiome and Clinical Course in Patients with Critical Care Illnesses. Microb Ecol. 2023 Oct;86(3):1814-1828. doi: 10.1007/s00248-023-02224-8. Epub 2023 May 3. PubMed PMID: 37133495.

13.  Pant A, Das B, Arimbasseri GA. Host microbiome in tuberculosis: disease, treatment, and immunity perspectives. Front Microbiol. 2023;14:1236348. doi: 10.3389/fmicb.2023.1236348. eCollection 2023. Review. PubMed PMID: 37808315; PubMed Central PMCID: PMC10559974.

14.  Rizvi ZA, Dandotiya J, Sadhu S, Khatri R, Singh J, Singh V, Adhikari N, Sharma K, Das V, Pandey AK, Das B, Medigeshi G, Mani S, Bhatnagar S, Samal S, Pandey AK, Garg PK, Awasthi A. Omicron sub-lineage BA.5 infection results in attenuated pathology in hACE2 transgenic mice. Commun Biol. 2023 Sep 13;6(1):935. doi: 10.1038/s42003-023-05263-6. PubMed PMID: 37704701; PubMed Central PMCID: PMC10499788.

15.  Mehrotra T, Konar D, Pragasam AK, Kumar S, Jana P, Babele P, Paul D, Purohit A, Tanwar S, Bakshi S, Das S, Verma J, Talukdar D, Narendrakumar L, Kothidar A, Karmakar SP, Chaudhuri S, Pal S, Jain K, Srikanth CV, Sankar MJ, Atmakuri K, Agarwal R, Gaind R, Ballal M, Kammili N, Bhadra RK, Ramamurthy T, Nair GB, Das B. Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis. Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2305465120. doi: 10.1073/pnas.2305465120. Epub 2023 Aug 7. PubMed PMID: 37549252; PubMed Central PMCID: PMC10434301.

16.  Taneja J, Chatterjee K, Sasidharan J, Abbas SZ, Rai AK, Raychaudhury S, Das B, Das A. Post-COVID-19 rhino-orbito-cerebral mucormycosis-A clinico-mycological study from North India. Med Mycol. 2023 Jul 6;61(7). doi: 10.1093/mmy/myad067. PubMed PMID: 37442616.

17.  Pant A, Maiti TK, Mahajan D, Das B.Human Gut Microbiota and Drug Metabolism. Microb Ecol. 2023 Jul;86(1):97-111. doi: 10.1007/s00248-022-02081-x. Epub 2022 Jul 23. Review. PubMed PMID: 35869999; PubMed Central PMCID: PMC9308113.

18.  Talukdar D, Bandopadhyay P, Ray Y, Paul SR, Sarif J, D'Rozario R, Lahiri A, Das S, Bhowmick D, Chatterjee S, Das B, Ganguly D. Association of gut microbial dysbiosis with disease severity, response to therapy and disease outcomes in Indian patients with COVID-19. Gut Pathog. 2023 May 10;15(1):22. doi: 10.1186/s13099-023-00546-z. PubMed PMID: 37161621; PubMed Central PMCID: PMC10170741.

19.  Ahrodia T, Kandiyal B, Das B. Microbiota and epigenetics: Health impact. Prog Mol Biol Transl Sci. 2023;198:93-117. doi: 10.1016/bs.pmbts.2023.03.018. Epub 2023 May 4. PubMed PMID: 37225326.

20.  Nii T, Maeda Y, Motooka D, Naito M, Matsumoto Y, Ogawa T, Oguro-Igashira E, Kishikawa T, Yamashita M, Koizumi S, Kurakawa T, Okumura R, Kayama H, Murakami M, Sakaguchi T, Das B, Nakamura S, Okada Y, Kumanogoh A, Takeda K. Genomic repertoires linked with pathogenic potency of arthritogenic Prevotella copri isolated from the gut of patients with rheumatoid arthritis. Ann Rheum Dis. 2023 May;82(5):621-629. doi: 10.1136/ard-2022-222881. Epub 2023 Jan 10. PubMed PMID: 36627170; PubMed Central PMCID: PMC10176341.

21.  Dutta S, Das B, Ghosh TS, Kumar S, Kaushal RK, Ray P, Suri V, Nair GB. Human Milk Microbiome of Healthy Indian Mothers is Dominated by Genus Pseudomonas. J Hum Lact. 2023 May;39(2):343-352. doi: 10.1177/08903344211048415. Epub 2021 Sep 28. PubMed PMID: 34581614.

22.  Deshpande S, Ansari MY, Sutar J, Das P, Hingankar N, Mukherjee S, Jayal P, Singh S, Anantharaj A, Singh J, Chattopadhyay S, Raghavan S, Gosain M, Chauhan S, Shrivas S, Prasad C, Chauhan S, Sharma N, Jana P, Thiruvengadam R, Kshetrapal P, Wadhwa N, Das B, Batra G, Medigeshi G, Sok D, Bhatnagar S, Garg PK, Bhattacharya J. Ancestral SARS-CoV-2-Driven Antibody Repertoire Diversity in an Unvaccinated Individual Correlates with Expanded Neutralization Breadth. Microbiol Spectr. 2023 Mar 22;11(2):e0433222. doi: 10.1128/spectrum.04332-22. [Epub ahead of print] PubMed PMID: 36946746; PubMed Central PMCID: PMC10100905.

23.  Panwar S, Kumari S, Verma J, Bakshi S, Narendrakumar L, Paul D, Das B. Toxin-linked mobile genetic elements in major enteric bacterial pathogens. Gut Microbiome (Camb). 2023;4:e5. doi: 10.1017/gmb.2023.2. eCollection 2023. Review. PubMed PMID: 39295911; PubMed Central PMCID: PMC11406385.

24.  Chowdhury G, Das B, Kumar S, Pant A, Mukherjee P, Ghosh D, Koley H, Miyoshi SI, Okamoto K, Paul A, Dutta S, Ramamurthy T, Mukhopadyay AK. Genomic insights into extensively drug-resistant Pseudomonas aeruginosa isolated from a diarrhea case in Kolkata, India. Future Microbiol. 2023 Feb;18:173-186. doi: 10.2217/fmb-2022-0140. Epub 2023 Mar 14. PubMed PMID: 36916516.

25.  Narendrakumar L, Chakraborty M, Kumari S, Paul D, Das B. β-Lactam potentiators to re-sensitize resistant pathogens: Discovery, development, clinical use and the way forward. Front Microbiol. 2022;13:1092556. doi: 10.3389/fmicb.2022.1092556. eCollection 2022. Review. PubMed PMID: 36970185; PubMed Central PMCID: PMC10036598.

26.  Das B, Mahajan D, Rakonjac J. Editorial: Antibiotic potentiators against drug-resistant pathogens: Discovery, development and clinical applications. Front Microbiol. 2023;14:1173906. doi: 10.3389/fmicb.2023.1173906. eCollection 2023. PubMed PMID: 36960280; PubMed Central PMCID: PMC10028237.

27.  Kumar S, Mehrotra T, Talukdar D, Verma J, Chandra Karmakar B, Paul S, Chaudhuri S, Kumari Pragasam A, Bakshi S, Kumari S, Chawla M, Purohit A, Porey Karmakar S, Mutreja A, Banerjee S, Ray A, Ramamurthy T, Mukhopadyay AK, Das B. Region-specific genomic signatures of multidrug-resistant Helicobacter pylori isolated from East and South India. Gene. 2022 Dec 30;847:146857. doi: 10.1016/j.gene.2022.146857. Epub 2022 Sep 11. PubMed PMID: 36100116.

28.  Lal S, Kandiyal B, Ahuja V, Takeda K, Das B. Gut microbiome dysbiosis in inflammatory bowel disease. Prog Mol Biol Transl Sci. 2022;192(1):179-204. doi: 10.1016/bs.pmbts.2022.09.003. Epub 2022 Oct 3. PubMed PMID: 36280319.

29.  Pavan S, Prabhu AN, Prasad Gorthi S, Das B, Mutreja A, Shetty V, Ramamurthy T, Ballal M. Exploring the multifactorial aspects of Gut Microbiome in Parkinson's Disease. Folia Microbiol (Praha). 2022 Oct;67(5):693-706. doi: 10.1007/s12223-022-00977-2. Epub 2022 May 18. Review. PubMed PMID: 35583791; PubMed Central PMCID: PMC9526693.

30.  Ahrodia T, Yodhaanjali JR, Das B. Vaginal microbiome dysbiosis in preterm birth. Prog Mol Biol Transl Sci. 2022;192(1):309-329. doi: 10.1016/bs.pmbts.2022.08.001. Epub 2022 Sep 11. PubMed PMID: 36280323.

31.  Alam MJ, Puppala V, Uppulapu SK, Das B, Banerjee SK. Human microbiome and cardiovascular diseases. Prog Mol Biol Transl Sci. 2022;192(1):231-279. doi: 10.1016/bs.pmbts.2022.07.012. Epub 2022 Sep 11. PubMed PMID: 36280321.

32.  Paul D, Das B. Gut microbiome in the emergence of antibiotic-resistant bacterial pathogens. Prog Mol Biol Transl Sci. 2022;192(1):1-31. doi: 10.1016/bs.pmbts.2022.07.009. Epub 2022 Sep 3. PubMed PMID: 36280316.

33.  Chawla M, Gupta R, Das B. Gut microbiome dysbiosis in malnutrition. Prog Mol Biol Transl Sci. 2022;192(1):205-229. doi: 10.1016/bs.pmbts.2022.07.011. Epub 2022 Aug 30. PubMed PMID: 36280320.

34.  Verma J, Sankar MJ, Atmakuri K, Agarwal R, Das B. Gut microbiome dysbiosis in neonatal sepsis. Prog Mol Biol Transl Sci. 2022;192(1):125-147. doi: 10.1016/bs.pmbts.2022.07.010. Epub 2022 Aug 30. PubMed PMID: 36280317.

35.  Pant A, Das B. Microbiome-based therapeutics: Opportunity and challenges. Prog Mol Biol Transl Sci. 2022;191(1):229-262. doi: 10.1016/bs.pmbts.2022.07.006. Epub 2022 Aug 22. PubMed PMID: 36270680.

36.  Purohit A, Alam MJ, Kandiyal B, Shalimar, Das B, Banerjee SK. Gut microbiome and non-alcoholic fatty liver disease. Prog Mol Biol Transl Sci. 2022;191(1):187-206. doi: 10.1016/bs.pmbts.2022.07.004. Epub 2022 Aug 22. PubMed PMID: 36270678.

37.  Ahrodia T, Das S, Bakshi S, Das B. Structure, functions, and diversity of the healthy human microbiome. Prog Mol Biol Transl Sci. 2022;191(1):53-82. doi: 10.1016/bs.pmbts.2022.07.003. Epub 2022 Aug 18. PubMed PMID: 36270682.

38.  Garg H, Das B, Bansal A, Kaushal R, Desai P, Maheshwari R, Chaturvedi S, Singh A, Kumar A. Trifecta and Pentafecta Outcomes in Laparoscopic and Robotic Nephron-Sparing Surgery for Highly Complex Renal Tumors: A Propensity Score-Matched Cohort Analysis. J Endourol. 2022 Aug;36(8):1050-1056. doi: 10.1089/end.2021.0830. Epub 2022 Mar 10. PubMed PMID: 35176904.

39.  Das B.An introduction to human microbiome. Prog Mol Biol Transl Sci. 2022;191(1):1-28. doi: 10.1016/bs.pmbts.2022.06.026. Epub 2022 Jul 30. PubMed PMID: 36270674.

40.  Chowdhury G, Ramamurthy T, Das B, Ghosh D, Okamoto K, Miyoshi SI, Dutta S, Mukhopadhyay AK. Characterization of NDM-5 Carbapenemase-Encoding Gene (bla (NDM-5)) - Positive Multidrug Resistant Commensal Escherichia coli from Diarrheal Patients. Infect Drug Resist. 2022;15:3631-3642. doi: 10.2147/IDR.S364526. eCollection 2022. PubMed PMID: 35837541; PubMed Central PMCID: PMC9275505.

41.  Ramamurthy T, Pragasam AK, Taylor-Brown A, Will RC, Vasudevan K, Das B, Srivastava SK, Chowdhury G, Mukhopadhyay AK, Dutta S, Veeraraghavan B, Thomson NR, Sharma NC, Nair GB, Takeda Y, Ghosh A, Dougan G, Mutreja A. Vibrio cholerae O139 genomes provide a clue to why it may have failed to usher in the eighth cholera pandemic. Nat Commun. 2022 Jul 5;13(1):3864. doi: 10.1038/s41467-022-31391-4. PubMed PMID: 35790755; PubMed Central PMCID: PMC9256687.

42.  Chawla M, Verma J, Gupta R, Das B. Antibiotic Potentiators Against Multidrug-Resistant Bacteria: Discovery, Development, and Clinical Relevance. Front Microbiol. 2022;13:887251. doi: 10.3389/fmicb.2022.887251. eCollection 2022. Review. PubMed PMID: 35847117; PubMed Central PMCID: PMC9284026.

43.  Yadav AK, Banerjee SK, Das B, Chaudhary K. Editorial: Systems Biology and Omics Approaches for Understanding Complex Disease Biology. Front Genet. 2022;13:896818. doi: 10.3389/fgene.2022.896818. eCollection 2022. PubMed PMID: 35495146; PubMed Central PMCID: PMC9039331.

44.  Medigeshi GR, Batra G, Murugesan DR, Thiruvengadam R, Chattopadhyay S, Das B, Gosain M, Ayushi, Singh J, Anbalagan A, Shaman H, Pargai K, Mehdi F, Das SJ, Kahlon N, Singh S, Kshetrapal P, Wadhwa N, Pandey AK, Bhatnagar S, Garg PK. Sub-optimal neutralisation of omicron (B.1.1.529) variant by antibodies induced by vaccine alone or SARS-CoV-2 Infection plus vaccine (hybrid immunity) post 6-months. EBioMedicine. 2022 Apr;78:103938. doi: 10.1016/j.ebiom.2022.103938. Epub 2022 Mar 16. PubMed PMID: 35305396; PubMed Central PMCID: PMC8923830.

45.  Bir R, Gautam H, Arif N, Chakravarti P, Verma J, Banerjee S, Tyagi S, Mohapatra S, Sood S, Dhawan B, Chaudhry R, Kapil A, Das BK, Das B. Analysis of colistin resistance in carbapenem-resistant Enterobacterales and XDR Klebsiella pneumoniae. Ther Adv Infect Dis. 2022 Jan-Dec;9:20499361221080650. doi: 10.1177/20499361221080650. eCollection 2022 Jan-Dec. PubMed PMID: 35237435; PubMed Central PMCID: PMC8883296.

46.  Biswas Q, Purohit A, Kumar A, Rakshit D, Maiti D, Das B, Bhadra RK. Genetic and mutational analysis of virulence traits and their modulation in an environmental toxigenic Vibrio cholerae non-O1/non-O139 strain, VCE232. Microbiology (Reading). 2022 Feb;168(2). doi: 10.1099/mic.0.001135. PubMed PMID: 35113781.

47.  Aggarwal H, Pathak P, Singh V, Kumar Y, Shankar M, Das B, Jagavelu K, Dikshit M. Vancomycin-Induced Modulation of Gram-Positive Gut Bacteria and Metabolites Remediates Insulin Resistance in iNOS Knockout Mice. Front Cell Infect Microbiol. 2021;11:795333. doi: 10.3389/fcimb.2021.795333. eCollection 2021. PubMed PMID: 35127558; PubMed Central PMCID: PMC8807491.

48.  Das B,Singh V. Preface. Prog Mol Biol Transl Sci. 2022;191(1):xiii-xiv. doi: 10.1016/S1877-1173(22)00142-9. PubMed PMID: 36270684.

49.  Mehrotra T, Devi TB, Kumar S, Talukdar D, Karmakar SP, Kothidar A, Verma J, Kumari S, Alexander SM, Retnakumar RJ, Devadas K, Ray A, Mutreja A, Nair GB, Chattopadhyay S, Das B. Antimicrobial resistance and virulence in Helicobacter pylori: Genomic insights. Genomics. 2021 Nov;113(6):3951-3966. doi: 10.1016/j.ygeno.2021.10.002. Epub 2021 Oct 5. PubMed PMID: 34619341.

50.  Kumar M, Kumar J, Sharma S, Hussain MA, Shelly A, Das B, Yadav AK, Mazumder S. TLR22-mediated activation of TNF-α-caspase-1/IL-1β inflammatory axis leads to apoptosis of Aeromonas hydrophila-infected macrophages. Mol Immunol. 2021 Sep;137:114-123. doi: 10.1016/j.molimm.2021.06.025. Epub 2021 Jul 6. PubMed PMID: 34242920.

51.  Chowdhury G, Senapati T, Das B, Kamath A, Pal D, Bose P, Deb A, Paul S, Mukhopadhyay AK, Dutta S, Ramamurthy T. Laboratory evaluation of the rapid diagnostic tests for the detection of Vibrio cholerae O1 using diarrheal samples. PLoS Negl Trop Dis. 2021 Jun;15(6):e0009521. doi: 10.1371/journal.pntd.0009521. eCollection 2021 Jun. PubMed PMID: 34129602; PubMed Central PMCID: PMC8232436.

52.  Kumar S, Kumari N, Talukdar D, Kothidar A, Sarkar M, Mehta O, Kshetrapal P, Wadhwa N, Thiruvengadam R, Desiraju BK, Nair GB, Bhatnagar S, Mukherjee S, Das B. The Vaginal Microbial Signatures of Preterm Birth Delivery in Indian Women. Front Cell Infect Microbiol. 2021;11:622474. doi: 10.3389/fcimb.2021.622474. eCollection 2021. PubMed PMID: 34094994; PubMed Central PMCID: PMC8169982.

53.  Will RC, Ramamurthy T, Sharma NC, Veeraraghavan B, Sangal L, Haldar P, Pragasam AK, Vasudevan K, Kumar D, Das B, Heinz E, Melnikov V, Baker S, Sangal V, Dougan G, Mutreja A. Spatiotemporal persistence of multiple, diverse clades and toxins of Corynebacterium diphtheriae. Nat Commun. 2021 Mar 8;12(1):1500. doi: 10.1038/s41467-021-21870-5. PubMed PMID: 33686077; PubMed Central PMCID: PMC7940655.

54.  Pinna NK, Anjana RM, Saxena S, Dutta A, Gnanaprakash V, Rameshkumar G, Aswath S, Raghavan S, Rani CSS, Radha V, Balasubramanyam M, Pant A, Nielsen T, Jørgensen T, Færch K, Kashani A, Silva MCA, Vestergaard H, Hansen TH, Hansen T, Arumugam M, Nair GB, Das B, Pedersen O, Mohan V, Mande SS. Trans-ethnic gut microbial signatures of prediabetic subjects from India and Denmark. Genome Med. 2021 Mar 3;13(1):36. doi: 10.1186/s13073-021-00851-9. PubMed PMID: 33658065; PubMed Central PMCID: PMC7931552.

55.  Alvarez-Silva C, Kashani A, Hansen TH, Pinna NK, Anjana RM, Dutta A, Saxena S, Støy J, Kampmann U, Nielsen T, Jørgensen T, Gnanaprakash V, Gnanavadivel R, Sukumaran A, Rani CSS, Færch K, Radha V, Balasubramanyam M, Nair GB, Das B, Vestergaard H, Hansen T, Mande SS, Mohan V, Arumugam M, Pedersen O. Trans-ethnic gut microbiota signatures of type 2 diabetes in Denmark and India. Genome Med. 2021 Mar 3;13(1):37. doi: 10.1186/s13073-021-00856-4. PubMed PMID: 33658058; PubMed Central PMCID: PMC7931542.

56.  Kedia S, Ghosh TS, Jain S, Desigamani A, Kumar A, Gupta V, Bopanna S, Yadav DP, Goyal S, Makharia G, Travis SPL, Das B, Ahuja V. Gut microbiome diversity in acute severe colitis is distinct from mild to moderate ulcerative colitis. J Gastroenterol Hepatol. 2021 Mar;36(3):731-739. doi: 10.1111/jgh.15232. Epub 2020 Sep 14. PubMed PMID: 32870508.

57.  Devi TB, Devadas K, George M, Gandhimathi A, Chouhan D, Retnakumar RJ, Alexander SM, Varghese J, Dharmaseelan S, Chandrika SK, Jissa VT, Das B, Nair GB, Chattopadhyay S. Low Bifidobacterium Abundance in the Lower Gut Microbiota Is Associated With Helicobacter pylori-Related Gastric Ulcer and Gastric Cancer. Front Microbiol. 2021;12:631140. doi: 10.3389/fmicb.2021.631140. eCollection 2021. PubMed PMID: 33717022; PubMed Central PMCID: PMC7953064.

58.  Das B,Bhadra RK. (p)ppGpp Metabolism and Antimicrobial Resistance in Bacterial Pathogens. Front Microbiol. 2020;11:563944. doi: 10.3389/fmicb.2020.563944. eCollection 2020. Review. PubMed PMID: 33162948; PubMed Central PMCID: PMC7581866.

59.  Kumar A, Das B, Kumar N. Vibrio Pathogenicity Island-1: The Master Determinant of Cholera Pathogenesis. Front Cell Infect Microbiol. 2020;10:561296. doi: 10.3389/fcimb.2020.561296. eCollection 2020. Review. PubMed PMID: 33123494; PubMed Central PMCID: PMC7574455.

60.  Rakshit D, Dasgupta S, Das B, Bhadra RK. Functional Insights Into the Role of gppA in (p)ppGpp Metabolism of Vibrio cholerae. Front Microbiol. 2020;11:564644. doi: 10.3389/fmicb.2020.564644. eCollection 2020. PubMed PMID: 33117311; PubMed Central PMCID: PMC7552824.

61.  Pant A, Bag S, Saha B, Verma J, Kumar P, Banerjee S, Kumar B, Kumar Y, Desigamani A, Maiti S, Maiti TK, Banerjee SK, Bhadra RK, Koley H, Dutta S, Nair GB, Ramamurthy T, Das B. Molecular insights into the genome dynamics and interactions between core and acquired genomes of Vibrio cholerae. Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23762-23773. doi: 10.1073/pnas.2006283117. Epub 2020 Sep 1. PubMed PMID: 32873641; PubMed Central PMCID: PMC7519391.

62.  Mehta O, Ghosh TS, Kothidar A, Gowtham MR, Mitra R, Kshetrapal P, Wadhwa N, Thiruvengadam R, Nair GB, Bhatnagar S, Das B. Vaginal Microbiome of Pregnant Indian Women: Insights into the Genome of Dominant Lactobacillus Species. Microb Ecol. 2020 Aug;80(2):487-499. doi: 10.1007/s00248-020-01501-0. Epub 2020 Mar 23. PubMed PMID: 32206831.

63.  Ramamurthy T, Das B, Chakraborty S, Mukhopadhyay AK, Sack DA. Diagnostic techniques for rapid detection of Vibrio cholerae O1/O139. Vaccine. 2020 Feb 29;38 Suppl 1:A73-A82. doi: 10.1016/j.vaccine.2019.07.099. Epub 2019 Aug 16. Review. PubMed PMID: 31427135.

64.  Pant A, Das B, Bhadra RK. CTX phage of Vibrio cholerae: Genomics and applications. Vaccine. 2020 Feb 29;38 Suppl 1:A7-A12. doi: 10.1016/j.vaccine.2019.06.034. Epub 2019 Jul 1. Review. PubMed PMID: 31272871.

65.  Das B,Verma J, Kumar P, Ghosh A, Ramamurthy T. Antibiotic resistance in Vibrio cholerae: Understanding the ecology of resistance genes and mechanisms. Vaccine. 2020 Feb 29;38 Suppl 1:A83-A92. doi: 10.1016/j.vaccine.2019.06.031. Epub 2019 Jul 2. Review. PubMed PMID: 31272870.

66.  Chatterjee P, Nagi N, Agarwal A, Das B, Banerjee S, Sarkar S, Gupta N, Gangakhedkar RR. The 2019 novel coronavirus disease (COVID-19) pandemic: A review of the current evidence. Indian J Med Res. 2020 Feb & Mar;151(2 & 3):147-159. doi: 10.4103/ijmr.IJMR_519_20. Review. PubMed PMID: 32362642; PubMed Central PMCID: PMC7357405.

67.  Pareek S, Kurakawa T, Das B, Motooka D, Nakaya S, Rongsen-Chandola T, Goyal N, Kayama H, Dodd D, Okumura R, Maeda Y, Fujimoto K, Nii T, Ogawa T, Iida T, Bhandari N, Kida T, Nakamura S, Nair GB, Takeda K. Comparison of Japanese and Indian intestinal microbiota shows diet-dependent interaction between bacteria and fungi. NPJ Biofilms Microbiomes. 2019;5(1):37. doi: 10.1038/s41522-019-0110-9. eCollection 2019. PubMed PMID: 31885873; PubMed Central PMCID: PMC6925221.

68.  Sharma NC, Efstratiou A, Mokrousov I, Mutreja A, Das B, Ramamurthy T. Diphtheria. Nat Rev Dis Primers. 2019 Dec 5;5(1):81. doi: 10.1038/s41572-019-0131-y. Review. PubMed PMID: 31804499.

69.  Das B,Nair GB. Homeostasis and dysbiosis of the gut microbiome in health and disease. J Biosci. 2019 Oct;44(5). Review. PubMed PMID: 31719226.

70.  Senapati T, Kothidar A, Banerjee SK, Das B. Insights into the gastrointestinal tract microbiomes of Indian population. J Biosci. 2019 Oct;44(5). Review. PubMed PMID: 31719222.

71.  Das B.Insights into TLCΦ lysogeny: A twist in the mechanism of IMEX integration. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18159-18161. doi: 10.1073/pnas.1912633116. Epub 2019 Aug 22. PubMed PMID: 31439815; PubMed Central PMCID: PMC6744843.

72.  Ramamurthy T, Mutreja A, Weill FX, Das B, Ghosh A, Nair GB. Corrigendum: Revisiting the Global Epidemiology of Cholera in Conjunction With the Genomics of Vibrio cholerae. Front Public Health. 2019;7:237. doi: 10.3389/fpubh.2019.00237. eCollection 2019. PubMed PMID: 31497590; PubMed Central PMCID: PMC6716542.

73.  Ramamurthy T, Mutreja A, Weill FX, Das B, Ghosh A, Nair GB. Revisiting the Global Epidemiology of Cholera in Conjuction With the Genomics of Vibrio cholerae. Front Public Health. 2019;7:203. doi: 10.3389/fpubh.2019.00203. eCollection 2019. Review. PubMed PMID: 31396501; PubMed Central PMCID: PMC6664003.

74.  Das B,Chattoraj DK. Commentary: Functionality of Two Origins of Replication in Vibrio cholerae Strains With a Single Chromosome. Front Microbiol. 2019;10:1314. doi: 10.3389/fmicb.2019.01314. eCollection 2019. PubMed PMID: 31275259; PubMed Central PMCID: PMC6594386.

75.  Verma J, Bag S, Saha B, Kumar P, Ghosh TS, Dayal M, Senapati T, Mehra S, Dey P, Desigamani A, Kumar D, Rana P, Kumar B, Maiti TK, Sharma NC, Bhadra RK, Mutreja A, Nair GB, Ramamurthy T, Das B. Genomic plasticity associated with antimicrobial resistance in Vibrio cholerae. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6226-6231. doi: 10.1073/pnas.1900141116. Epub 2019 Mar 13. PubMed PMID: 30867296; PubMed Central PMCID: PMC6442563.

76.  Bag S, Ghosh TS, Banerjee S, Mehta O, Verma J, Dayal M, Desigamani A, Kumar P, Saha B, Kedia S, Ahuja V, Ramamurthy T, Das B. Molecular Insights into Antimicrobial Resistance Traits of Commensal Human Gut Microbiota. Microb Ecol. 2019 Feb;77(2):546-557. doi: 10.1007/s00248-018-1228-7. Epub 2018 Jul 16. PubMed PMID: 30009332.

77.  Adela R, Reddy PNC, Ghosh TS, Aggarwal S, Yadav AK, Das B, Banerjee SK. Serum protein signature of coronary artery disease in type 2 diabetes mellitus. J Transl Med. 2019 Jan 24;17(1):17. doi: 10.1186/s12967-018-1755-5. PubMed PMID: 30674322; PubMed Central PMCID: PMC6345069.

78.  Das B,Ghosh TS, Kedia S, Rampal R, Saxena S, Bag S, Mitra R, Dayal M, Mehta O, Surendranath A, Travis SPL, Tripathi P, Nair GB, Ahuja V. Analysis of the Gut Microbiome of Rural and Urban Healthy Indians Living in Sea Level and High Altitude Areas. Sci Rep. 2018 Jul 4;8(1):10104. doi: 10.1038/s41598-018-28550-3. PubMed PMID: 29973712; PubMed Central PMCID: PMC6031670.

79.  Kumar A, Bag S, Das B. Novel Genetic Tool to Study the Stability of Genomic Islands. Recent Pat Biotechnol. 2018;12(3):200-207. doi: 10.2174/1872208312666180223113618. PubMed PMID: 29473528.

80.  Bag S, Ghosh TS, Das B. Complete Genome Sequence of Collinsella aerofaciens Isolated from the Gut of a Healthy Indian Subject. Genome Announc. 2017 Nov 22;5(47). doi: 10.1128/genomeA.01361-17. PubMed PMID: 29167267; PubMed Central PMCID: PMC5701492.

81.  Bag S, Ghosh TS, Das B. Complete Genome Sequence of Faecalibacterium prausnitzii Isolated from the Gut of a Healthy Indian Adult. Genome Announc. 2017 Nov 16;5(46). doi: 10.1128/genomeA.01286-17. PubMed PMID: 29146862; PubMed Central PMCID: PMC5690339.

82.  Das A, Pereira V, Saxena S, Ghosh TS, Anbumani D, Bag S, Das B, Nair GB, Abraham P, Mande SS. Gastric microbiome of Indian patients with Helicobacter pylori infection, and their interaction networks. Sci Rep. 2017 Nov 13;7(1):15438. doi: 10.1038/s41598-017-15510-6. PubMed PMID: 29133866; PubMed Central PMCID: PMC5684312.

83.  Kumar P, Bag S, Ghosh TS, Dey P, Dayal M, Saha B, Verma J, Pant A, Saxena S, Desigamani A, Rana P, Kumar D, Sharma NC, Hanpude P, Maiti TK, Mukhopadhyay AK, Bhadra RK, Nair GB, Ramamurthy T, Das B. Molecular Insights into Antimicrobial Resistance Traits of Multidrug Resistant Enteric Pathogens isolated from India. Sci Rep. 2017 Oct 31;7(1):14468. doi: 10.1038/s41598-017-14791-1. PubMed PMID: 29089611; PubMed Central PMCID: PMC5663842.

84.  Bag S, Ghosh TS, Das B. Whole-Genome Sequence of a Megasphaera elsdenii Strain Isolated from the Gut of a Healthy Indian Adult Subject. Genome Announc. 2017 Oct 19;5(42). doi: 10.1128/genomeA.01033-17. PubMed PMID: 29051237; PubMed Central PMCID: PMC5646390.

85.  Bag S, Ghosh TS, Das B. Whole-Genome Sequence of Bifidobacterium longum Strain Indica, Isolated from the Gut of a Healthy Indian Adult. Genome Announc. 2017 Oct 12;5(41). doi: 10.1128/genomeA.01017-17. PubMed PMID: 29025929; PubMed Central PMCID: PMC5637489.

86.  Srivastava N, Shelly A, Kumar M, Pant A, Das B, Majumdar T, Mazumder S. Aeromonas hydrophila utilizes TLR4 topology for synchronous activation of MyD88 and TRIF to orchestrate anti-inflammatory responses in zebrafish. Cell Death Discov. 2017;3:17067. doi: 10.1038/cddiscovery.2017.67. eCollection 2017. PubMed PMID: 29142761; PubMed Central PMCID: PMC5680545.

87.  Bag S, Ghosh TS, Das B. Draft Genome Sequence of Prevotella copri Isolated from the Gut of a Healthy Indian Adult. Genome Announc. 2017 Sep 14;5(37). doi: 10.1128/genomeA.00834-17. PubMed PMID: 28912310; PubMed Central PMCID: PMC5597751.

88.  Das B, Chaudhuri S, Srivastava R, Nair GB, Ramamurthy T. Fostering research into antimicrobial resistance in India. BMJ. 2017 Sep 6;358:j3535. doi: 10.1136/bmj.j3535. PubMed PMID: 28877874; PubMed Central PMCID: PMC5582344.

89.  Rakonjac J, Das B, Derda R. Editorial: Filamentous Bacteriophage in Bio/Nano/Technology, Bacterial Pathogenesis and Ecology. Front Microbiol. 2016;7:2109. doi: 10.3389/fmicb.2016.02109. eCollection 2016. PubMed PMID: 28066406; PubMed Central PMCID: PMC5179506.

90.  Chowdhury G, Bhadra RK, Bag S, Pazhani GP, Das B, Basu P, Nagamani K, Nandy RK, Mukhopadhyay AK, Ramamurthy T. Rugose atypical Vibrio cholerae O1 El Tor responsible for 2009 cholera outbreak in India. J Med Microbiol. 2016 Oct;65(10):1130-1136. doi: 10.1099/jmm.0.000344. Epub 2016 Aug 25. PubMed PMID: 27561681.

91.  Das B, Pazhani GP, Sarkar A, Mukhopadhyay AK, Nair GB, Ramamurthy T. Molecular evolution and functional divergence of Vibrio cholerae. Curr Opin Infect Dis. 2016 Oct;29(5):520-7. doi: 10.1097/QCO.0000000000000306. Review. PubMed PMID: 27537830.

92.  Bag S, Saha B, Mehta O, Anbumani D, Kumar N, Dayal M, Pant A, Kumar P, Saxena S, Allin KH, Hansen T, Arumugam M, Vestergaard H, Pedersen O, Pereira V, Abraham P, Tripathi R, Wadhwa N, Bhatnagar S, Prakash VG, Radha V, Anjana RM, Mohan V, Takeda K, Kurakawa T, Nair GB, Das B. An Improved Method for High Quality Metagenomics DNA Extraction from Human and Environmental Samples. Sci Rep. 2016 May 31;6:26775. doi: 10.1038/srep26775. PubMed PMID: 27240745; PubMed Central PMCID: PMC4886217.

93.  Pant A, Anbumani D, Bag S, Mehta O, Kumar P, Saxena S, Nair GB, Das B. Effect of LexA on Chromosomal Integration of CTXϕ in Vibrio cholerae. J Bacteriol. 2016 Jan 15;198(2):268-75. doi: 10.1128/JB.00674-15. Print 2016 Jan 15. PubMed PMID: 26503849; PubMed Central PMCID: PMC4751795.

94.  Das B, Kumari R, Pant A, Sen Gupta S, Saxena S, Mehta O, Nair GB. A novel, broad-range, CTXΦ-derived stable integrative expression vector for functional studies. J Bacteriol. 2014 Dec;196(23):4071-80. doi: 10.1128/JB.01966-14. Epub 2014 Sep 15. PubMed PMID: 25225263; PubMed Central PMCID: PMC4248877.

95.  Das B. Mechanistic insights into filamentous phage integration in Vibrio cholerae. Front Microbiol. 2014;5:650. doi: 10.3389/fmicb.2014.00650. eCollection 2014. Review. PubMed PMID: 25506341; PubMed Central PMCID: PMC4246890.

96.  Midonet C, Das B, Paly E, Barre FX. XerD-mediated FtsK-independent integration of TLCϕ into the Vibrio cholerae genome. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16848-53. doi: 10.1073/pnas.1404047111. Epub 2014 Nov 10. PubMed PMID: 25385643; PubMed Central PMCID: PMC4250166.

97.  Kim EJ, Lee D, Moon SH, Lee CH, Kim SJ, Lee JH, Kim JO, Song M, Das B, Clemens JD, Pape JW, Nair GB, Kim DW. Molecular insights into the evolutionary pathway of Vibrio cholerae O1 atypical El Tor variants. PLoS Pathog. 2014 Sep;10(9):e1004384. doi: 10.1371/journal.ppat.1004384. eCollection 2014 Sep. PubMed PMID: 25233006; PubMed Central PMCID: PMC4169478.

98.  Bag S, Das B, Dasgupta S, Bhadra RK. Mutational analysis of the (p)ppGpp synthetase activity of the Rel enzyme of Mycobacterium tuberculosis. Arch Microbiol. 2014 Aug;196(8):575-88. doi: 10.1007/s00203-014-0996-9. Epub 2014 May 24. PubMed PMID: 24859914.

99.  Ghosh TS, Gupta SS, Bhattacharya T, Yadav D, Barik A, Chowdhury A, Das B, Mande SS, Nair GB. Gut microbiomes of Indian children of varying nutritional status. PLoS One. 2014;9(4):e95547. doi: 10.1371/journal.pone.0095547. eCollection 2014. PubMed PMID: 24763225; PubMed Central PMCID: PMC3999041.

100.  Banerjee R, Das B, Balakrish Nair G, Basak S. Dynamics in genome evolution of Vibrio cholerae. Infect Genet Evol. 2014 Apr;23:32-41. doi: 10.1016/j.meegid.2014.01.006. Epub 2014 Jan 23. Review. PubMed PMID: 24462909.

101.   Das B, Martínez E, Midonet C, Barre FX. Integrative mobile elements exploiting Xer recombination. Trends Microbiol. 2013 Jan;21(1):23-30. doi: 10.1016/j.tim.2012.10.003. Epub 2012 Nov 2. Review. PubMed PMID: 23127381.

102.   Pal RR, Bag S, Dasgupta S, Das B, Bhadra RK. Functional characterization of the stringent response regulatory gene dksA of Vibrio cholerae and its role in modulation of virulence phenotypes. J Bacteriol. 2012 Oct;194(20):5638-48. doi: 10.1128/JB.00518-12. Epub 2012 Aug 17. PubMed PMID: 22904284; PubMed Central PMCID: PMC3458680.

103. Majumdar T, Das B, Bhadra RK, Dam B, Mazumder S. Complete nucleotide sequence of a quinolone resistance gene (qnrS2) carrying plasmid of Aeromonas hydrophila isolated from fish. Plasmid. 2011 Jul;66(2):79-84. doi: 10.1016/j.plasmid.2011.05.001. Epub 2011 Jun 12. PubMed PMID: 21664930.

104. Das B, Bischerour J, Barre FX. VGJphi integration and excision mechanisms contribute to the genetic diversity of Vibrio cholerae epidemic strains. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2516-21. doi: 10.1073/pnas.1017061108. Epub 2011 Jan 24. PubMed PMID: 21262799; PubMed Central PMCID: PMC3038760.

105.  Pal RR, Das B, Dasgupta S, Bhadra RK. Genetic components of stringent response in Vibrio cholerae. Indian J Med Res. 2011 Feb;133(2):212-7. Review. PubMed PMID: 21415497; PubMed Central PMCID: PMC3089054.

106. Das B, Bischerour J, Barre FX. Molecular mechanism of acquisition of the cholera toxin genes. Indian J Med Res. 2011 Feb;133(2):195-200. Review. PubMed PMID: 21415494; PubMed Central PMCID: PMC3089051.

107.  Das B, Bischerour J, Val ME, Barre FX. Molecular keys of the tropism of integration of the cholera toxin phage. Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4377-82. doi: 10.1073/pnas.0910212107. Epub 2010 Jan 21.

• BOOK/BOOK CHAPTERS

  
  21. Ahrodia T, Kandiyal B, Das B. Microbiota and epigenetics: Health impact. Prog Mol Biol Transl Sci. 2023;198:93-117. doi: 10.1016/bs.pmbts.2023.03.018. Epub 2023 May 4. PMID: 37225326.

   

  20. Das B. (2022). An introduction to human microbiome. Prog Mol Biol Transl Sci. 2022;191(1):1-28. doi: 10.1016/bs.pmbts.2022.06.026. Epub 2022 Jul 30. PMID: 36270674.

  
  19. Pant A,   Das B. (2022). Microbiome-based therapeutics: Opportunity and challenges. Prog Mol Biol Transl Sci. 2022;191(1):229-262. doi: 10.1016/bs.pmbts.2022.07.006. Epub 2022 Aug 22. PMID: 36270680.

  
  18.Paul D.,  Das B. (2022). Gut microbiome in the emergence of antibiotic-resistant bacterial pathogens. Prog Mol Biol Transl Sci. 2022;192(1):1-31. doi: 10.1016/bs.pmbts.2022.07.009. Epub 2022 Sep 3. PMID: 36280316.

  
  17. Ahrodia T, Das S, Bakshi S, Das B. (2022). Structure, functions, and diversity of the healthy human microbiome. Prog Mol Biol Transl Sci. 2022;191(1):53-82. doi: 10.1016/bs.pmbts.2022.07.003. Epub 2022 Aug 18. PMID: 36270682.

  
  16. Ahrodia T, Yodhaanjali JR, Das B. (2022). Vaginal microbiome dysbiosis in preterm birth. Prog Mol Biol Transl Sci. 2022;192(1):309-329. doi: 10.1016/bs.pmbts.2022.08.001. Epub 2022 Sep 11. PMID: 36280323.

  
  15. Chawla M, Gupta R, Das B. (2022). Gut microbiome dysbiosis in malnutrition. Prog Mol Biol Transl Sci. 2022;192(1):205-229. doi: 10.1016/bs.pmbts.2022.07.011. Epub 2022 Aug 30. PMID: 36280320.

  
  14. Kandiyal B, Ahuja V, Takeda K, Das B. (2022). Gut microbiome dysbiosis in inflammatory bowel disease. Prog Mol Biol Transl Sci. 2022;192(1):179-204. doi: 10.1016/bs.pmbts.2022.09.003. Epub 2022 Oct 3. PMID: 36280319.

  
  13. J, Sankar MJ, Atmakuri K, Agarwal R, Das B. (2022).Gut microbiome dysbiosis in neonatal sepsis. Prog Mol Biol Transl Sci. 2022;192(1):125-147. doi: 10.1016/bs.pmbts.2022.07.010. Epub 2022 Aug 30. PMID: 36280317.

  
  12. A, Alam MJ, Kandiyal B, Shalimar, Das B., Banerjee SK. (2022) Gut microbiome and non-alcoholic fatty liver disease. Prog Mol Biol Transl Sci. 2022;191(1):187-206. doi: 10.1016/bs.pmbts.2022.07.004. Epub 2022 Aug 22. PMID: 36270678.

   

• 11. Alam MJ, Puppala V, Uppulapu SK, Das B., Banerjee SK. (2022) Human microbiome and cardiovascular diseases. Prog Mol Biol Transl Sci. 2022;192(1):231-279. doi: 10.1016/bs.pmbts.2022.07.012. Epub 2022 Sep 11. PMID: 36280321.

   

• 10. Ahrodia T., Wadhwa N., Das B.(2021) Gut Microbiome Signatures in Health and Diseases. Elsevier Food Science, ISBN 9780081005965, doi.org/10.1016/B978-0-12-819265-8.00067-X

   

  9. Ramamurthy T., Mukhopadhyay A. Das B.Nandy R., Mutreja A., Weill F.X., Nair G.B. (2020) Molecular Typing of Vibrio cholerae:Imprints in the Epidemiology of Cholerain“Molecular Typing in Bacterial Infections” Editors: Ivano de Filippis and Marian L. McKee. Publisher: Springer Nature Publishing. ISBN: 978-1-62703-185-1

   

  8. Matta T., Purohit A., Das B. (2020). "Human reproductive tract microbiome and birth outcomes" in “Recent Advances in Obstetrics and Gynaecology”. Editor: Aruna Nigam. Evangel Publisher. 

   

  7. Das B.,Saxena S., Mehta O., Bhadra R.K., Nair G.B. (2019). The human microbiota in health and disease. In Probiotics in Health: Emerging Opportunities (Edited by Takeda Y., Nair G.B., Kurpad A.). Publisher: Wiley India.

   

  6. eBook (2017): Filamentous Bacteriophage in Bio/Nano/Technology, Bacterial Pathogenesis and Ecology. Edited by: Rakonjac J., Das B., Derda R. Publisher: Frontiers Media SA. ISBN: 9782889450954

   

• 5. Dasgupta S., Das B.,Basu P., Bhadra R.K. (2016) Molecular basis of stringent response in Vibrio cholerae (Edited by Frans J. de Bruijn. John Wiley & Sons, Inc, USA). P. 507-516 Aug 2016

   

  4. Nair G.B., Sen Gupta S., Das B. (2014). The “Uncultured” but significant world of the human gut microbiome: New metagenomic insights. In G. P. Talwar and L.M. Srivastava (Eds.), Textbook of Biochemistry and Human Biology (pp. 664-671). Delhi, India: PHI Learning Pvt. Ltd.   

   

  3. Das B.and Nair G.B. (2012). The genomics of Cholera. In ‘Genomics Applications for the Developing World’ (Eds. Karen E. Nelson & Barbara jones-Nelson) Springer publication, USA pp. 21-38, DOI: 10.1007/978-1-4614-2182-5_3.

   

  2. Bhadra R.K., Shah S., Das B.(2010). Small Molecule Signaling Systems in Vibrio cholerae.  In ‘Epidemiological and Molecular Aspects on Cholera’ (Eds. Ramamurthy T. & Bhattacharya S. K.). Humana Press, USA, pp. 185-201.

   

  1. Bhadra R.K. and Das B. (2008). Coordinated regulation of gene expression in Vibrio cholerae. In ‘Vibrio cholerae: Genomics and Molecular Biology’ (Eds. Faruque, S.M. & Nair, G.B). Caister Academic Press, UK, pp. 153-167.

 

 

Abstract

1. D Paul, J Verma, B Das (2023) A Rapid Point-of-Care Dipstick Assay for Differentiation of Sars-Cov-2 Variants in Covid-19 Patients. International Journal of Infectious Diseases 130, S24

 

2. J Taneja, R Ranjan, K Chatterjee, V Ramesh, B Das (2022) Phaeohyphomycosis caused by Rhinocladiella similis mimicking Sporotrichosis. Medical Mycology 60 (S1), 167

 

 

3. J Taneja, K Chatterjee, J Sasidharan, Z Abbas, AK Rai, B Das (2022) Clinical outcome and in vitro antifungal susceptibility of clinical isolates of rhino-orbito-cerebral mycosis associated with post COVID 19 from North India

 

 

• Bhabatosh Das, Chawla M, Paul D, Mahajan D. Aminoglycoside and chloramphenicol potentiators against multi-drug-resistant bacterial pathogens and their use thereof. application no. 202411070536. Year: 2024
• Bhabatosh Das, Lekshmi N., Paul D. A genetic tool for engineering the genome of bacteria and a method of preparing the same thereof. Application no. 202411056506. Year: 2024
• Bhabatosh Das, Daizee Talukdar, Yodhanjali JR, Shinjini Bhatnagar, Nitya Wadhwa. Composition of Lactobacillus crispatus for nutraceutical and therapeutic uses and methods thereof. Patent application no. 202411066896. Year: 2024
• Bhabatosh Das, Lekshmi N., Chawla M, Paul D. Title: Genetically engineered bacterial reporter strain and a method of preparing the same there of. Patent application no. 202411035814. Year: 2024
• Bhabatosh Das, Shruti Panwar, Nitya Wadhwa, Roshan Kumar: Title: Universal microbial sample transport medium for genomic and metagenomic studies. Patent application no. 202211023269. Year: 2022
• Bhabatosh Das, Archana Pant, Jyoti Verma, Shailendra Vyas: Title: Integrative Expression Vector. Patent application no. 201911046890; Year: 2019.

• Fellow of the National Academy of Sciences, India (2024)

• S. Ramachandran National Bioscience Award (2023)

• Bill and Melinda Gates Foundation Award to attend Grand Challenges Annual Meeting in Dakar, Senegal (2023)

• Fellow of the West Bengal Academy of Science & Technology (2022)

• Young Scientist Award from International Life Sciences Institute-India for Improving Public Health in the Areas of Food Safety, Nutrition and Wellbeing (2021)

• Bill and Melinda Gates Foundation Award to attend US-Japan Joint Panel Conference on Cholera and Other Bacterial Enteric Infections (2018)

• Japan Society for the Promotion of Science (JSPS) Invitational Fellowship Award (2017). 

• Invited Member of GTFCC in World Health Organization (WHO) (2010-Till)

• Young Investigator Award (1^st prize) from Yakult India Microbiota and Probiotic Science Foundation, 2016

 

Editorial Board Member

• Microbial Ecology (Editorial Board Member)

• Gut Microbiome (Editorial Board Member)

• Frontiers in Microbiology (Guest Associate Editor)

• Frontiers in Genetics (Guest Associate Editor)

• EC Microbiology (Editorial Board Member)

 

• Best Poster Award in Conference/Symposium

 •    Best Poster Award (2018) in Biozest 2018 for research on CTX-phage replication and integration. Organizers: South Asian University, New Delhi on 6th December 2018.
      Title: Deciphering the host bacterial factors essential for integration and replication of CTX-phage
      Presenting author: Archana Pant, Corresponding author: Bhabatosh Das.

•    Best Poster Award (2018) in the international Probiotic Symposium “Probiotics through the Lifespan” for research on the Gut Microbiome and Antimicrobial resistance (24th-25th November 2018). Organizers:  NICED, Kolkata; ILDS, Kolkata; Amity University, Kolkata.         
     Title: Gut microbiome is the epicenter for dissemination of antimicrobial resistance traits
     Presenting author: Jyoti Verma, Corresponding author: Bhabatosh Das.

•    Best Poster Award (2018) for Antimicrobial resistance research in the international Probiotic Symposium, “ Probiotics through the Lifespan” (24-25 Nov. 2018). Organizers: NICED, Kolkata; ILDS, Kolkata; Amity University, Kolkata.
     Title: Role of gut microbiota in the emergence of colistin resistant enteric pathogens
     Presenting author: Tarosi Senapati, Corresponding author: Bhabatosh Das.      

•    Best Poster Award (2018)  in the International Symposium on Infectious Diseases (12-14 November) for Antimicrobial resistance research. Organizer: Regional Centre for Biotechnology, Faridabad and Jamia Hamdard, Delhi.
     Title: Insights into the resistance traits of multidrug resistant enteric pathogens isolated from India
     Presenting author: Satyabrata Bag, Corresponding author: Bhabatosh Das.  

•    Best Poster Award (2018)  in the International Conference on Anti‐Microbial Resistance (16-17 Feb. 2018) for Antimicrobial resistance research. Organizer: NIPER, Kolkata and NICED Kolkata.
     Title: Molecular insights into antimicrobial resistance traits of multi drug resistant commensal human gut microbiota
     Presenting author: Satyabrata Bag, Corresponding author: Bhabatosh Das.  

•    Best Poster Award (2018) in the NIPGR and THSTI Open day (28th September) for Antimicrobial resistance research.
     Title: Antibiotic resistance in commensal and pathogenic bacteria
     Presenting author: Jyoti Verma, Corresponding author: Bhabatosh Das.
 
•    Best Poster Award (2017) in “Cardiovascular Research Convergence” conference on 12th and 19th August 2017 for Human Microbiome research . Organizers: AIIMS-Delhi and THSTI-Faridabad.
     Title: Gut Microbiome in Inflammatory Bowel Disease: A Comparative analysis in the Indian population
     Presenting author: Tarini Shankar Ghosh. Corresponding author: Bhabatosh Das

•    Best Poster Award (2017)  in “THSTI foundation day for Human Microbiome research. Organizer: THSTI.
     Title: Insights into the Gut Microbiome of Inflammatory Bowel Disease patients living in different parts of India
     Presenting author: Tarini Shankar Ghosh. Corresponding author: Bhabatosh Das.

 

       Title: Genome Editing for Next-Gen Probiotics

 

Guest Speaker: (2022) 16^th Asian Conference on Diarrhoeal Disease and Nutrition (ASCODD-2022) organized by the National Institute of Cholera and Enteric Diseases               (NICED) on 11^th – 13^th

November 2022 at Kolkata

Title: Next generation sequencing technologies: Advances and applications in research and diagnostics 

 

Guest Speaker: (2022) Annual meeting organized by the International Life Sciences Institute India on 12^th October 2022 at New Delhi

Title: Human microbiome in health and disease 

 

Guest Speaker: (2022) International conference on A Gateway to Understand Complex Pancreatic Disorders organized by the Indian Pancreatic Club on 8^th – 9^th October             2022 at New Delhi

Title: Basic of Human microbiome

 

Guest Speaker: (2022) 16^th Asian Conference on Diarrhoeal Disease and Nutrition (ASCODD-2022) organized by the National Institute of Cholera and Enteric Diseases               (NICED) on 11^th – 13^th

November 2022 at Kolkata

Title: Homeostasis and Dysbiosis of human microbiome in health and disease

 

Guest Speaker: (2022) One-day symposium on Inflammation Organized by the Translational Health Science and Technology Institute on 14^th July 2022

Title: Inflammation and microbiome

 

Guest Speaker: (2022) The Vaginal Microbiome Research Consortium 2022 annual meeting organized by the Bill and Melinda Gates Foundation on 7^th January 2022

Title: Vaginal microbial signature in birth outcomes in the GARBH-Ini pregnancy cohort 

 

Guest Speaker: (2022) Seminar on Antimicrobial Resistance organized by the Ruhvenile Biomedical Pvt. Ltd. Delhi on 23^rd April 2022

Title: Antibiotic potentiator: A key to unlock antibiotic resistance

 

Guest Speaker: (2022) One-day Symposium on Metabolic Associated Fatty Liver Disease Organized by the Translational Health Science and Technology Institute on 25              May 2022

Title: Geo-Specific Signature of Gut Microbiome Associated with NAFLD

 

Guest Speaker: (2022) Science Setu Talk organized by the Translational Health Science and Technology Institute.

Title: Micro-organisms that live in and on the human body 

 

Guest Speaker: (2021) Grand challenges Annual Meeting 2021 at Boston, USA organized by the Bill and Melinda Gates Foundation on 8-11 November 2021

Title: Reproductive tract microbiome in Indian women associated with preterm birth

 

Guest Speaker (Webinar talk 2021): 10^th National Conference (AOGIN) on infections and neoplasia organized by the AIIMS-New Delhi

Title: Dysbiosis of reproductive tract microbiota in Preterm birth 

 

Guest Speaker (Webinar talk 2021): Organized by the Calcutta University on 1st March 2021.

Title: Genetic nature and dynamics of antibiotic resistance traits in the commensal and pathogenic enteric bacteria

 

Guest Speaker (Webinar talk 2021): Organized by the Amrtita Vishwa Vidyapeetham on 26 February 2021.

Title: Genomics of Extensively Drug Resistant Enteric Bacterial Pathogens Isolated from India

 

Guest Speaker (Webinar talk 2021): Organized by the Savitribai Phule Pune University, Pune on 2nd February 2021

Title: Understanding role of human gut microbiome in the emergence and spread of antibiotic resistant enteric bacterial pathogens

 

Guest Speaker (2020, webinar talk) organised by the Dept. of Gastroenterology, AIIMS New Delhi on 18^th August 2020

Title: Homeostasis and Dysbiosis of the Human Gut Microbiome in Health and Diseases

 

Guest Speaker (2020, webinar talk) organised by the School of Biotechnology, Presidency University, Kolkata on 6-7 August 2020

Title: Human Microbiome in Health and Diseases

 

Guest Speaker (2020, webinar talk) organised by the Dept. of Science and Technology (DST), Govt. of Rajasthan on 12th April 2020

Title: Human Microbiome in Health and Diseases

 

Guest Speaker (2020, webinar talk) organised by the Sidho-Kanho-Birsha-University, WB on 8^th June 2020

Title: Molecular insights into COVID-19 and its pathogen SARS-CoV-2

 

Guest Speaker (2020, webinar talk) organised by the Adamas University, Kolkata on 6^th July 2020.

Title: Gut Microbiome: Associations, Functions and Implications for therapeutics

 

Guest Speaker (2020): 10^th India probiotic symposium on “Cutting edge science and applications: Intestinal microbiota and Probiotics” organized by the Probiotic Science             Foundation on 29^th

February-1^st March 2020 at The Suryaa, New Delhi.

Title: Diet and the Gut Microbiome: Applications, Functions and Implications for Therapeutics.

 

Keynote Speaker (2019): Seminar on "Current Challenges of antimicrobial Resistance and Potential Intervention by Bacteriophages" organized by the ICMR-NICED on            16th and 17th September at

Hyatt Regency Kolkata.

Title: Insights into Antimicrobial Resistance in Human Associated Microbes.

 

Guest Speaker (2019): International India|EMBO Symposium on Human Microbiome organized by J. Craig Venter Institute, US and National Institute of Biomedical                       Genomics, IN on 9-12 Nov, 2019.

Title: Role of vaginal microbiome in preterm birth

 

Guest Speaker (2019): National seminar on Next Generation DNA sequencing organized by the Pondicherry University, India on 12-13 Dec, 2019.

Title: Next Generation Sequencing Technology and Application.

 

Guest Speaker (2019): National Institute of Pharmaceutical Education and Research (NIPER) Kolkata on 7th November 2019.

Title: Insights into antibiotic resistance in human associated gut microbiota

 

Guest Speaker  (2019): Frontiers in Biological Sciences. Organizers: (i) St. Xavier's College, (ii) Presidency University (iii) CSIR-IICB, Kolkata. 

Title: Understanding the role of human gut microbiome in the emergence of antibiotic resistant enteric bacterial pathogens

 

Guest Speaker (2019):  Workshop on Translational Health at The International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi on 11^th - 15^th March           2019.

Title: Structure, functions and dynamics of gut microbiome of Indian population living in rural and urban areas.

 

Guest Speaker (2019): All India Institute of Medical Sciences (AIIMS), New Delhi (2^nd March. 2019)

Title: Metagenomics

 

Guest Speaker (2019):  All India Institute of Medical Sciences (AIIMS), New Delhi (23^rd Feb. 2019)

Title: Human Microbiome: Concept, Approaches and Implications

 

Guest Speaker International Conference on “Role of Probiotics in Promoting Healthy Microbiome for Health and Immunity” organized by International Life Science Institute-           India, New Delhi on 6^th December 2018.

Title: Impact of Microbial Community DNA Extraction Method on Human Microbiome Study

 

Guest Speaker 9^th India Probiotic Symposium organized by the Gut Microbiota and Probiotic Science Foundation in association with Amity University, Kolkata, National                 Institute of Cholera and Enteric Diseases (NICED), Kolkata and the Indian Institute of Liver and Digestive Sciences, Kolkata on 24^th - 25^th November 2018.

Title: Gut Microbiome of Healthy Indian Population Living in Urban and Rural Areas

 

Guest Speaker International Conference on Microbiome Research (ICMR) 2018, National Centre For Cell Science, Pune on 19^th - 22^nd November 2018.

Title: Gut Microbiome of Indian Population in Health and Diseases

 

Guest Speaker Institute of Life Sciences, Bhubaneswar 4^th September 2018.

Title: Gut Microbiome of Indian Population in Health and Diseases

 

Guest Speaker Workshop and seminar on Translational research in biomedical and agricultural sciences, All India Institute of Medical Sciences, New Delhi, 6^th – 7^th July               2018.

Title: Molecular Insights into Antimicrobial Resistance Traits of Human Gut Microbiota

 

Guest Speaker Manipal Academy of Higher Education, Manipal 14^th March 2018

Title: Current Understanding of the Human Microbiome

 

Guest Speaker Current trends in Genomics at Aligarh Muslim University, Aligarh on 21 March 2018.

Title: Genomics of commensal and pathogenic enteric bacteria: AMR perspectives 

 

Guest Speaker NASH-context and Research at Indian Institute of liver and digestive Sciences, Kolkata on 6^th February 2018.

Title: Microbiome and Metabolic Diseases

 

Guest Speaker Graduate School of Medicine, Osaka University, Japan on 27^th October 2017.

Title: Insights into Gut Microbiome of Indian Population in Health and Diseases

(1) Nutra Ingradients USA (24 September 2018)

Title: Microbiome insights

https://www.nutraingredients-usa.com/Article/2018/09/24/NutraIngredients-USA-Global-Round-up-Increasing-B2-production-Amway-in-India-and-more

 

(2) The Hindu (26^th August 2018)

Title: A nursery of drug resistance

https://www.thehindu.com/sci-tech/health/a-nursery-of-drug-resistance/article24782373.ece

 

(3) BusinessLines (21st August 2018)

Gut bacteria are a reservoir of drug resistance genes: study

https://www.thehindubusinessline.com/news/science/gut-bacteria-are-a-reservoir-of-drug-resistance-genes-study/article24744954.ece

 

(4) Nature India(29 July 2018)

Pathogens pick up drug resistance genes from friendly bacteria

https://www.natureasia.com/en/nindia/article/10.1038/nindia.2018.95

 

(5) Nature India (July11, 2018)

Rural Indians have healthier guts than urban folks

https://www.natureasia.com/en/nindia/article/10.1038/nindia.2018.88

 

(6) Dept. of Biotechnology, Govt. of India (July 23, 2018)

Richness, functions and diversity of the gut microbiome of healthy Indians

http://www.dbtindia.nic.in/gut-microbiome-of-healthy-indians/

 

(7) Vigyan Prasar, Dept. of Science and Technology, Govt. of India (July 19, 2018)

A peek into gut of Indians throws up surprises

http://vigyanprasar.gov.in/isw/peek_into_gut_indians_throwsup_surprises_story.html

 

(8) The Hindu (July 22, 2018)

What your gut is telling you

https://www.thehindu.com/sci-tech/health/what-your-gut-is-telling-you/article24485083.ece

 

(9) Hindustan Times (July 22, 2018)

Vegetarian diet helps keep Indian gut healthy: Study

https://www.hindustantimes.com/health/vegetarian-diet-helps-keep-indian-gut-healthy-study/story-9fEx1ypTnvOlm1y9zoJKzL.html

 

(10) Deccan Herald (23rd July, 2018)

Scientists map gut microbiota of Indians

https://www.deccanherald.com/national/scientists-map-gut-microbiota-682983.html

 

(11) The Hindu (15th October 2017)

We need to talk about AMR

https://www.thehindu.com/todays-paper/tp-opinion/we-need-to-talk-about-amr/article19864066.ece

 

(12) Fountain ink (17th May 2017)

The body’s secret garden: How the exploration of the microbiome is going to change face of medicine

https://fountainink.in/reportage/the-body039s-secret-garden

 

(13) Dept. of Biotechnology, Govt. of India (2015)

Scientists in THSTI Develop Novel Genetic Tools to speed up Drug Discovery Research

http://www.dbtindia.nic.in/scientists-in-thsti-develop-novel-genetic-tools-to-speed-up-drug-discovery-research/

 

(14) Times of India (Aug 17, 2015)

Research roundup: Vector-wise

https://timesofindia.indiatimes.com/home/education/news/Researcg-roundup-Vector-wise/articleshow/48511390.cms

 

(14) Times of India (Aug 17, 2015)

Research roundup: Vector-wise

 

https://timesofindia.indiatimes.com/home/education/news/Researcg-roundup-Vector-wise/articleshow/48511390.cms

DR. PRADIPTA JANA
SENIOR TECHNICAL OFFICER
MS. SHASHI KUMARI
PH.D STUDENT
MS. MEENAL CHAWLA
PH.D STUDENT
MS. TANSHI MEHROTRA
PH.D STUDENT
MS. BHARTI
PH.D STUDENT
MR. ROSHAN KUMAR
LAB TECHNICIAN
MS. SHRUTI LAL
PROJECT ASSOCIATE-I
MS. SHREYA SARKAR
PROJECT ASSOCIATE-I
MS. KAJAL KAMBOJ
PH.D STUDENT
DR. MAHENDRA DEVIDAS JAMDHADE
TECHNICAL OFFICER-I
DR. DAIZEE TALUKDAR
RESEARCH SCIENTIST
MS. PRIYANKA VERMA
PH.D STUDENT
MS. NISHA
TECHNICAL ASSISTANT
DR. UPMA SINGH
RESEARCH ASSOCIATE-I
MS. SUSMITA BAKSHI
SENIOR PROJECT ASSOCIATE
MS. NISHTHA BHARDWAJ
PROJECT ASSOCIATE-I
DR. PRABHAKAR BABELE
RESEARCH SCIENTIST
MR. SANBARTA GANGULY
TECHNICAL ASSISTANT
MS. PREETI
LAB TECHNICIAN
DR. DEEPJYOTI PAUL
RESEARCH SCIENTIST
MS. CHANDANA BASAK
SENIOR PROJECT ASSOCIATE
MS. VAISHALI GUPTA
PROJECT RESEARCH SCIENTIST-I
MS. MANJARI GUPTA
PROJECT TECHNICAL SUPPORT-III
DR. MANJEET KAUR
PROJECT RESEARCH SCIENTIST-II
MS. RENU MAANZU
PROJECT ASSOCIATE-I
DR. LEKSHMI N.
RESEARCH SCIENTIST